Ojuawo A, Milla P J, Lindley K J
Gastroenterology Unit, Institute of Child Health, London.
West Afr J Med. 1998 Jul-Sep;17(3):206-9.
Serum immunoglobulin and immunoglobulin G subclasses were measured in thirty children with histologically proven allergic colitis and twenty age matched controls. Serum immunoglobulin A (mean +/- sd) (0.45 +/- 0.25 vs 87 +/- 0.41 Gm/L), IgG2 (29.2 +/- 13.1 vs 49.5 +/- 12.8 mg/dL), and IgG4 (7.58 +/- 3.01 vs 11.2 +/- 2.59 mg/dL) were significantly lower in allergic colitis than in the controls respectively (p < 0.001). There was a significant elevation of serum IgE in those with allergic colitis (p < 0.01). The serum IgG1 and IgG3 levels were not significantly different in allergic colitis and the controls (p > 0.10). Immunoglobulin A, IgG2 and IgG4 subclasses were low in 43.3%, 75.0% and 55.0% of cases of allergic colitis respectively, compared to 5.0% of the controls with low IgG2 and IgG4 (p < 0.005). The IgG1 and IgG3 subclasses were normal and comparable in both groups. Children with food allergic colitis in this study have low levels of IgG A, IgG2 and IgG4 subclasses. IgA, IgG2 and IgG4 subclass deficiency probably have a role to play in the pathogenesis of allergic colitis an mucosal immune defense mechanism.
对30名经组织学证实患有过敏性结肠炎的儿童和20名年龄匹配的对照组儿童进行了血清免疫球蛋白和免疫球蛋白G亚类检测。过敏性结肠炎患儿的血清免疫球蛋白A（均值±标准差）（0.45±0.25 vs 0.87±0.41 Gm/L）、IgG2（29.2±13.1 vs 49.5±12.8 mg/dL）和IgG4（7.58±3.01 vs 11.2±2.59 mg/dL）分别显著低于对照组（p<0.001）。过敏性结肠炎患儿的血清IgE显著升高（p<0.01）。过敏性结肠炎患儿与对照组的血清IgG1和IgG3水平无显著差异（p>0.10）。过敏性结肠炎患儿中免疫球蛋白A、IgG2和IgG4亚类降低的病例分别占43.3%、75.0%和55.0%，而对照组中IgG2和IgG4降低的病例占5.0%（p<0.005）。两组中IgG1和IgG3亚类均正常且相当。本研究中患有食物过敏性结肠炎的儿童IgG A、IgG2和IgG4亚类水平较低。IgA、IgG2和IgG4亚类缺乏可能在过敏性结肠炎的发病机制及黏膜免疫防御机制中起作用。
