Wilson Thomas J, Singh Rakesh K
Department of Pathology and Microbiology, The University of Nebraska Medical Center, Omaha, NE 68198-5845, USA.
Biochim Biophys Acta. 2008 Apr;1785(2):85-95. doi: 10.1016/j.bbcan.2007.11.001. Epub 2007 Nov 26.
As cells undergo oncogenic transformation and as malignant cells arrive at metastatic sites, a complex interplay occurs with the surrounding stroma. This dialogue between the tumor and stroma ultimately dictates the success of the tumor cells in the given microenvironment. As a result, understanding the molecular mechanisms at work is important for developing new therapeutic modalities. Proteases are major players in the interaction between tumor and stroma. This review will focus on the role of proteases in modulating tumor-stromal interactions of both primary breast and prostate tumors as well as at bone metastatic sites in a way that favors tumor growth.
随着细胞发生致癌转化以及恶性细胞到达转移部位，肿瘤细胞与周围基质之间会发生复杂的相互作用。肿瘤与基质之间的这种对话最终决定了肿瘤细胞在特定微环境中的成功与否。因此，了解其中起作用的分子机制对于开发新的治疗方法至关重要。蛋白酶是肿瘤与基质相互作用中的主要参与者。本综述将聚焦于蛋白酶在调节原发性乳腺癌和前列腺癌以及骨转移部位的肿瘤-基质相互作用中所起的作用，这些作用有利于肿瘤生长。
