胚胎干细胞中的基因靶向技术在斯德哥尔摩取得了一项基因敲除成果。

Gene targeting in embryonic stem cells scores a knockout in Stockholm.

作者信息

Mak Tak Wah

机构信息

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada M5G 2C1.

出版信息

Cell. 2007 Dec 14;131(6):1027-31. doi: 10.1016/j.cell.2007.11.033.

DOI:10.1016/j.cell.2007.11.033

PMID:18083089

Abstract

The 2007 Nobel Prize in Physiology or Medicine has been awarded to Mario Capecchi, Martin Evans, and Oliver Smithies for developing specific gene modification techniques and mouse embryonic stem cell technology that, when combined, enable the creation of "knockout" mice. Analyses of these mutant animals have revolutionized the elucidation of gene functions, and these mice have proved to be valuable models of numerous human diseases.

摘要

2007年诺贝尔生理学或医学奖授予马里奥·卡佩奇、马丁·埃文斯和奥利弗·史密斯，以表彰他们研发出特定的基因修饰技术和小鼠胚胎干细胞技术，二者结合后可培育出“基因敲除”小鼠。对这些突变动物的分析彻底改变了对基因功能的阐释，而且这些小鼠已被证明是众多人类疾病的宝贵模型。