Seo Takayuki, Pahwa Punam, McDuffie Helen H, Nakada Naoyuki, Goto Shuji, Ghosh Sunita, Nakagawa Kazuko
Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan.
Ann Epidemiol. 2008 Apr;18(4):330-4. doi: 10.1016/j.annepidem.2007.10.002. Epub 2008 Feb 20.
This retrospective longitudinal study investigated the association between the Q192R polymorphism of the high-density lipoprotein-associated multifunctional antioxidant enzyme, paraoxonase-1 (PON1), and lung function decline, while taking into account smoking history.
The demographic, occupational, and respiratory symptom information and lung function variables were obtained from 216 male Saskatchewan grain workers.
An interaction between the PON1 genotypes and smoking status was observed. Current smokers with the 192R allele had a lower forced expiratory volume in the first second (FEV(1)) and FEV(1) per forced vital capacity (FVC). The annual decline rate of FEV(1)/FVC in current smokers was greater among 192R allele carriers than noncarriers (0.58+/-0.05 vs. 0.35+/-0.04 %/yr, p<0.0001). A similar result was observed with FEV(1) (40.9+/-6.4 vs. -33.0+/-7.0 mL/yr, p=0.10). The annual decline rate of FVC was not influenced by the genotypes.
These results strengthened the previous findings of our cross-sectional study, suggesting that the 192R allele may be a novel genetic risk factor for airway injury among current smokers.
这项回顾性纵向研究调查了高密度脂蛋白相关多功能抗氧化酶对氧磷酶-1（PON1）的Q192R多态性与肺功能下降之间的关联，同时考虑了吸烟史。
从216名萨斯喀彻温省男性谷物工人那里获取了人口统计学、职业和呼吸症状信息以及肺功能变量。
观察到PON1基因类型与吸烟状况之间存在相互作用。携带192R等位基因的当前吸烟者在第一秒用力呼气量（FEV(1)）和每用力肺活量（FVC）的FEV(1)方面较低。在当前吸烟者中，192R等位基因携带者的FEV(1)/FVC年下降率高于非携带者（0.58±0.05对0.35±0.04%/年，p<0.0001）。FEV(1)也观察到类似结果（40.9±6.4对-33.0±7.0 mL/年，p=0.10）。FVC的年下降率不受基因类型影响。
这些结果强化了我们横断面研究先前的发现，表明192R等位基因可能是当前吸烟者气道损伤的一个新的遗传风险因素。
