Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, MD 21201, USA.
Office of Research and Scholarship, University of Maryland School of Nursing, Baltimore, MD 21201, USA.
Int J Environ Res Public Health. 2020 Sep 30;17(19):7165. doi: 10.3390/ijerph17197165.
Childhood wheeze may be related to pesticide exposure, and diet and genetics (Paroxonase; ) may modify the effects of exposure.
We analyzed data from the HOME Study, a prospective pregnancy and birth cohort, to examine the association of gestational urinary organophosphate (OP) and pyrethroid (3PBA) metabolite concentrations with child wheeze, forced expiratory volume in one second (FEV1) at ages 4 and 5 years, and wheeze trajectory patterns through age 8 years.
Among 367 singletons, the frequency of wheeze ranged from 10.6% to 24.1% at each measurement age. OP and 3PBA metabolite concentrations were not associated with wheeze at 8 years or from birth to 8 years, but there were three significant interactions: (1) maternal daily fruit and vegetable consumption (less than daily consumption and increasing 3PBA was associated with wheeze at age 8 years, OR = 1.40), (2) maternal allele (CT/TT genotypes and high DE was associated with wheeze at age 8 years, OR = 2.13, 2.74) and (3) alleles (QR/RR genotypes with higher diethylphosphate (DE) and dialkyl phosphate (DAP) were associated with wheeze at age 8 years, OR = 3.84). Pesticide metabolites were not consistently related to FEV1 or wheeze trajectory.
Gestational OP and 3PBA metabolites were associated with child respiratory outcomes in participants with maternal dietary and genetic susceptibility.
儿童喘息可能与农药暴露有关，饮食和遗传（对氧磷酶； ）可能会改变暴露的影响。
我们分析了 HOME 研究的数据，这是一项前瞻性的妊娠和出生队列研究，以研究妊娠尿液有机磷（OP）和拟除虫菊酯（3PBA）代谢物浓度与儿童喘息、4 岁和 5 岁时的一秒用力呼气量（FEV1）以及 8 岁时的喘息轨迹模式之间的关系。
在 367 名单胎中，每个测量年龄的喘息频率从 10.6%到 24.1%不等。OP 和 3PBA 代谢物浓度与 8 岁时的喘息或从出生到 8 岁时的喘息无关，但有三个显著的相互作用：（1）母亲每日水果和蔬菜的摄入量（低于每日摄入量和增加 3PBA 与 8 岁时的喘息有关，OR=1.40），（2）母亲 等位基因（CT/TT 基因型和高 DE 与 8 岁时的喘息有关，OR=2.13,2.74）和（3） 等位基因（QR/RR 基因型与较高的二乙基磷酸（DE）和二烷基磷酸（DAP）与 8 岁时的喘息有关，OR=3.84）。农药代谢物与 FEV1 或喘息轨迹没有一致的关系。
妊娠 OP 和 3PBA 代谢物与具有母体饮食和遗传易感性的参与者的儿童呼吸道结局有关。
