Departments of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama 35233.
Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35233.
J Neurosci. 2024 Oct 2;44(40):e0122242024. doi: 10.1523/JNEUROSCI.0122-24.2024.
Executive control of movement enables inhibiting impulsive responses critical for successful navigation of the environment. Circuits mediating stop commands involve prefrontal and basal ganglia structures with fMRI evidence demonstrating increased activity during response inhibition in the dorsolateral prefrontal cortex (dlPFC)-often ascribed to maintaining task attentional demands. Using direct intraoperative cortical recordings in male and female human subjects, we investigated oscillatory dynamics along the rostral-caudal axis of dlPFC during a modified Go/No-go task, probing components of both proactive and reactive motor control. We assessed whether cognitive control is topographically organized along this axis and observed that low-frequency power increased prominently in mid-rostral dlPFC when inhibiting and delaying responses. These findings provide evidence for a key role for mid-rostral dlPFC low-frequency oscillations in sculpting motor control.
运动的执行控制使抑制冲动反应成为可能，这对于成功导航环境至关重要。介导停止命令的回路涉及前额叶和基底神经节结构，功能磁共振成像证据表明，在背外侧前额叶皮层（dlPFC）中，反应抑制期间的活动增加-通常归因于维持任务注意力需求。使用男性和女性人类受试者的直接术中皮质记录，我们在修改后的 Go/No-go 任务中研究了 dlPFC 头侧-尾侧轴上的振荡动力学，探测了主动和反应性运动控制的组成部分。我们评估了认知控制是否沿着该轴进行拓扑组织，并观察到在抑制和延迟反应时，中间 dlPFC 的低频功率显著增加。这些发现为中间 dlPFC 低频振荡在塑造运动控制中的关键作用提供了证据。
