与乳糜泻相关的脱酰胺麦醇溶蛋白肽复合的人类白细胞抗原II类分子HLA - DQ2和HLA - DQ8的产生及结晶。
The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease.
作者信息
Henderson Kate N, Reid Hugh H, Borg Natalie A, Broughton Sophie E, Huyton Trevor, Anderson Robert P, McCluskey James, Rossjohn Jamie
机构信息
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia.
出版信息
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1021-5. doi: 10.1107/S1744309107051408. Epub 2007 Nov 21.
Abstract
The major histocompatibility complex (MHC) class II molecules HLA-DQ2 and HLA-DQ8 are key risk factors in coeliac disease, as they bind deamidated gluten peptides that are subsequently recognized by CD4+ T cells. Here, the production and crystallization of both HLA-DQ2 and HLA-DQ8 in complex with the deamidated gliadin peptides DQ2 alpha-I (PQPELPYPQ) and DQ8 alpha-I (EGSFQPSQE), respectively, are reported.
摘要
主要组织相容性复合体（MHC）II类分子HLA-DQ2和HLA-DQ8是乳糜泻的关键风险因素，因为它们结合脱酰胺麦醇溶蛋白肽，随后这些肽被CD4 + T细胞识别。在此，分别报道了HLA-DQ2和HLA-DQ8与脱酰胺麦醇溶蛋白肽DQ2α-I（PQPELPYPQ）和DQ8α-I（EGSFQPSQE）形成复合物的产生和结晶情况。
相似文献
1
The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease.与乳糜泻相关的脱酰胺麦醇溶蛋白肽复合的人类白细胞抗原II类分子HLA - DQ2和HLA - DQ8的产生及结晶。
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1021-5. doi: 10.1107/S1744309107051408. Epub 2007 Nov 21.
2
HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease.乳糜泻中麸质T细胞表位的HLA-DQ2和-DQ8特征
J Clin Invest. 2006 Aug;116(8):2226-36. doi: 10.1172/JCI27620. Epub 2006 Jul 27.
3
A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease.人类白细胞抗原DQ8在乳糜泻中作用的结构和免疫学基础。
Immunity. 2007 Jul;27(1):23-34. doi: 10.1016/j.immuni.2007.05.015. Epub 2007 Jul 12.
4
The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase.成年乳糜泻患者肠道T细胞对α-麦醇溶蛋白的反应集中于组织转谷氨酰胺酶靶向的单个脱酰胺谷氨酰胺。
J Exp Med. 2000 Feb 21;191(4):603-12. doi: 10.1084/jem.191.4.603.
5
Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells.在表达特异性抗麦醇溶蛋白CD4 + T细胞的人源化HLA - DR3 - DQ2转基因小鼠中对乳糜泻的抗性。
J Immunol. 2009 Jun 15;182(12):7440-50. doi: 10.4049/jimmunol.0900233.
6
Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer. gluten 特异性 T 细胞在 HLA-DQ8 和 HLA-DQ2α/DQ8β 转二聚体之间发生交叉反应。
J Immunol. 2011 Nov 15;187(10):5123-9. doi: 10.4049/jimmunol.1101179. Epub 2011 Oct 17.
7
Specific Genetic Polymorphisms Contributing in Differential Binding of Gliadin Peptides to HLA-DQ and TCR to Elicit Immunogenicity in Celiac Disease.特定的遗传多态性导致麦胶蛋白肽与 HLA-DQ 的不同结合以及与 TCR 的结合，从而引发乳糜泻的免疫原性。
Biochem Genet. 2023 Dec;61(6):2457-2480. doi: 10.1007/s10528-023-10377-x. Epub 2023 Apr 27.
8
Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes.与两种疾病特异性表位复合的乳糜泻相关HLA - DQ8和非相关HLA - DQ9等位基因的结构
Int Immunol. 2000 Aug;12(8):1157-66. doi: 10.1093/intimm/12.8.1157.
9
The role of HLA-DQ8 beta57 polymorphism in the anti-gluten T-cell response in coeliac disease.HLA-DQ8 β57多态性在乳糜泻抗麸质T细胞反应中的作用。
Nature. 2008 Nov 27;456(7221):534-8. doi: 10.1038/nature07524.
10
Design of gliadin peptide analogues with low affinity for the celiac disease associated HLA-DQ2 protein.对乳糜泻相关HLA-DQ2蛋白低亲和力的麦醇溶蛋白肽类似物的设计
Mol Biosyst. 2014 Aug;10(8):2064-73. doi: 10.1039/c4mb00085d.
引用本文的文献
1
MHC2-SCALE enhances identification of immunogenic neoantigens.MHC2-SCALE增强了免疫原性新抗原的识别。
iScience. 2025 Mar 13;28(4):112212. doi: 10.1016/j.isci.2025.112212. eCollection 2025 Apr 18.
2
Celiac Disease-Narrative Review on Progress in Celiac Disease.乳糜泻——乳糜泻进展的叙述性综述
Foods. 2025 Mar 11;14(6):959. doi: 10.3390/foods14060959.
3
Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease.描述一种针对乳糜泻患者多种谷蛋白肽：HLA-DQ2.5 复合物具有广泛反应性的中和抗体。
Nat Commun. 2023 Dec 22;14(1):8502. doi: 10.1038/s41467-023-44083-4.
4
Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism.免疫介导疾病的遗传学：从全基因组关联到分子机制
Curr Opin Immunol. 2014 Dec;31:51-7. doi: 10.1016/j.coi.2014.09.007. Epub 2014 Oct 14.
5
T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.T 细胞受体识别与乳糜泻相关的 HLA-DQ2-麦胶蛋白复合物。
Nat Struct Mol Biol. 2014 May;21(5):480-8. doi: 10.1038/nsmb.2817. Epub 2014 Apr 28.
6
Exploring T cell reactivity to gliadin in young children with newly diagnosed celiac disease.探索新诊断的乳糜泻幼儿对麦醇溶蛋白的T细胞反应性。
Autoimmune Dis. 2014;2014:927190. doi: 10.1155/2014/927190. Epub 2014 Mar 3.
7
Targeted modification of wheat grain protein to reduce the content of celiac causing epitopes.靶向修饰小麦籽粒蛋白以降低麦胶蛋白致敏性表位含量。
Funct Integr Genomics. 2012 Aug;12(3):417-38. doi: 10.1007/s10142-012-0287-y. Epub 2012 Jun 26.
8
Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data.通过脱水提高蛋白质晶体的X射线衍射能力：以牛血清白蛋白为例及文献数据综述
Int J Mol Sci. 2012;13(3):3782-3800. doi: 10.3390/ijms13033782. Epub 2012 Mar 21.
本文引用的文献
1
Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease.乳糜泻中HLA-DQ2介导的麸质表位呈递的结构基础
Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4175-9. doi: 10.1073/pnas.0306885101. Epub 2004 Mar 12.
2
Prevalence of Celiac disease among children in Finland.芬兰儿童乳糜泻的患病率。
N Engl J Med. 2003 Jun 19;348(25):2517-24. doi: 10.1056/NEJMoa021687.
3
T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase.来自乳糜泻病变部位的T细胞识别由内源性组织转谷氨酰胺酶原位脱酰胺的麦醇溶蛋白表位。
Eur J Immunol. 2001 May;31(5):1317-23. doi: 10.1002/1521-4141(200105)31:5<1317::AID-IMMU1317>3.0.CO;2-I.
4
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.人胰岛素肽-HLA-DQ8复合物的结构与1型糖尿病易感性
Nat Immunol. 2001 Jun;2(6):501-7. doi: 10.1038/88694.
5
The finer things in X-ray diffraction data collection.X射线衍射数据收集的精妙之处。
Acta Crystallogr D Biol Crystallogr. 1999 Oct;55(Pt 10):1718-25. doi: 10.1107/s090744499900935x.
6
An iceberg of childhood coeliac disease in the Netherlands.
Lancet. 1999 Mar 6;353(9155):813-4. doi: 10.1016/S0140-6736(99)00243-3.
7
High prevalence of celiac disease in apparently healthy blood donors suggests a high prevalence of undiagnosed celiac disease in the Dutch population.在看似健康的献血者中乳糜泻的高患病率表明荷兰人群中未被诊断出的乳糜泻患病率很高。
Scand J Gastroenterol. 1999 Mar;34(3):276-9. doi: 10.1080/00365529950173681.
8
Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity.组织转谷氨酰胺酶介导的选择性脱酰胺作用可显著增强麦醇溶蛋白特异性T细胞反应性。
J Immunol. 1998 Aug 15;161(4):1585-8.
9
Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes.利用多价可溶性II类主要组织相容性复合体共价肽复合物检测抗原特异性T细胞。
Immunity. 1998 Jun;8(6):675-82. doi: 10.1016/s1074-7613(00)80572-5.
10
Use of eluted peptide sequence data to identify the binding characteristics of peptides to the insulin-dependent diabetes susceptibility allele HLA-DQ8 (DQ 3.2).利用洗脱肽序列数据鉴定肽与胰岛素依赖型糖尿病易感等位基因HLA - DQ8（DQ 3.2）的结合特性。
Int Immunol. 1997 Jun;9(6):905-11. doi: 10.1093/intimm/9.6.905.
Zotero 插件