植物源化合物的药物发现与开发

Drug discovery and development with plant-derived compounds.

作者信息

Potterat Olivier, Hamburger Matthias

机构信息

University of Basel, Institute of Pharmaceutical Biology, Klingelbergstrasse 50, 4056 Basel, Switzerland.

出版信息

Prog Drug Res. 2008;65:45, 47-118. doi: 10.1007/978-3-7643-8117-2_2.

DOI:10.1007/978-3-7643-8117-2_2

PMID:18084913

Abstract

An overview is given on current efforts in drug development based on plant-derived natural products. Emphasis is on projects which have advanced to clinical development. Therapeutic areas covered include cancer, viral infections including HIV, malaria, inflammatory diseases, nociception and vaccine adjuvants, metabolic disorders, and neurodegenerative diseases. Aspects which are specific to plant-based drug discovery and development are also addressed, such as supply issues in the commercial development, and the Convention on Biological Diversity.

摘要

本文概述了基于植物源天然产物的药物研发的当前进展。重点介绍了已进入临床开发阶段的项目。涵盖的治疗领域包括癌症、包括艾滋病病毒在内的病毒感染、疟疾、炎症性疾病、疼痛感受和疫苗佐剂、代谢紊乱以及神经退行性疾病。还讨论了基于植物的药物发现和开发所特有的方面，例如商业开发中的供应问题以及《生物多样性公约》。