Gueguen B, Derouesné C, Bourdel M C, Guillou S, Landre E, Gaches J, Hossard H, Ancri D, Mann M
Service de neurophysiologie clinique, hôpital Sainte-Anne, Paris, France.
Neurophysiol Clin. 1991 Dec;21(5-6):357-71. doi: 10.1016/s0987-7053(05)80327-2.
79 subjects (mean age 70.2 ans, 31 males, 48 females) selected as probable dementia of the Alzheimer type, at the early stage of the disease and 17 normal aged people (mean age: 72.2, 5 males, 12 females) were recorded with a 16 channel computerized-EEG (C-EEG) with topographical analysis of the observed changes and with classical visual analysis of the EEG. Quite simple C-EEG parameters as mean dominant frequency (MF) and alpha to theta ratio are able to discriminate patients from normal with a greater accuracy than visual analysis. The values of 8.6 for the MF and 1.3 for the alpha/theta ratio are proposed as cut off values between normal and DAT patients. The topographical analysis appear to be of no additional usefulness in the discrimination of the two groups.
79名被选为可能患有阿尔茨海默型痴呆症的受试者（平均年龄70.2岁，男性31名，女性48名）处于疾病早期，以及17名正常老年人（平均年龄：72.2岁，男性5名，女性12名）接受了16通道计算机脑电图（C-EEG）记录，对观察到的变化进行地形分析，并对脑电图进行经典视觉分析。相当简单的C-EEG参数，如平均优势频率（MF）和α与θ比值，能够比视觉分析更准确地区分患者和正常人。建议将MF值8.6和α/θ比值1.3作为正常人与阿尔茨海默病患者之间的临界值。地形分析在区分两组时似乎没有额外的用处。
