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阿尔茨海默病型痴呆和亨廷顿病中脑电图活动的计算机分析

Computer analysis of EEG activity in dementia of the Alzheimer's type and Huntington's disease.

作者信息

Streletz L J, Reyes P F, Zalewska M, Katz L, Fariello R G

机构信息

Department of Neurology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA.

出版信息

Neurobiol Aging. 1990 Jan-Feb;11(1):15-20. doi: 10.1016/0197-4580(90)90057-7.

DOI:10.1016/0197-4580(90)90057-7
PMID:2139184
Abstract

Computer analysis of the EEG was obtained in the course of evaluation of 35 patients with Dementia of the Alzheimer's Type (DAT) and Huntington's disease (HD), and compared to 20 age-matched normal controls. On-line computer analysis of the EEG consisted of: 1) compressed spectral array (CSA) displays (2-6 channels); 2) relative frequency power (4 bands) and 3) an averaged frequency power function [( alpha/alpha + theta power (microV 2)] X 100 = % EEG Power function). Frequency power reflected increased theta, and reduced alpha components, in patient groups. Significant correlation was obtained between % EEG Power function, and clinical stage of dementia. This function correctly identified 17/25 DAT, and 7/10 HD patients, and gave additional quantification to the primary EEG.

摘要

在对35例阿尔茨海默型痴呆(DAT)和亨廷顿病(HD)患者进行评估的过程中,获取了脑电图(EEG)的计算机分析结果,并与20名年龄匹配的正常对照者进行了比较。EEG的在线计算机分析包括:1)压缩谱阵(CSA)显示(2 - 6个通道);2)相对频率功率(4个频段);3)平均频率功率函数[(α/α + θ功率(微伏²)]×100 = % EEG功率函数)。频率功率反映了患者组中θ增加和α成分减少的情况。% EEG功率函数与痴呆临床分期之间存在显著相关性。该函数正确识别了25例DAT患者中的17例,以及10例HD患者中的7例,并对原始EEG进行了额外的量化分析。

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