Müdüroğlu Kırmızıbekmez Aynur, Özdemir Mustafa Yasir, Önder Alparslan, Çatı Ceren, Kara İhsan
Department of Basic Science, İstanbul Nisantasi University, Istanbul 34400, Türkiye.
SANKARA Brain and Biotechnology Research Center, Technology Park, Istanbul University Cerrahpasa, Istanbul 34320, Türkiye.
Nutrients. 2025 Jul 24;17(15):2425. doi: 10.3390/nu17152425.
This study aimed to explore the acute neurophysiological effects of a single oral dose of Astragaloside IV (AS-IV) on EEG-measured brain oscillations and cognitive-relevant spectral markers in healthy young adults. Twenty healthy adults (8 females, 12 males; mean age: 23.4±2.1) underwent eyes-closed resting-state EEG recordings before and approximately 90 min after oral intake of 150 mg AS-IV. EEG data were collected using a 21-channel 10-20 system and cleaned via Artifact Subspace Reconstruction and Independent Component Analysis. Data quality was confirmed using a signal-to-noise ratio and 1/f spectral slope. Absolute and relative power values, band ratios, and frontal alpha asymmetry were computed. Statistical comparisons were made using paired -tests or Wilcoxon signed-rank tests. Absolute power decreased in delta, theta, beta, and gamma bands ( < 0.05) but remained stable for alpha. Relative alpha power increased significantly ( = 0.002), with rises in relative beta, theta, and delta and a drop in relative gamma ( = 0.003). Alpha/beta and theta/beta ratios increased, while delta/alpha decreased. Frontal alpha asymmetry was unchanged. Sex differences were examined in all measures that showed significant changes; however, no sex-dependent effects were found. A single AS-IV dose may acutely modulate brain oscillations, supporting its potential neuroactive properties. Larger placebo-controlled trials, including concurrent psychometric assessments, are needed to verify and contextualize these findings. A single AS-IV dose may acutely modulate brain oscillations, supporting its potential neuroactive properties.
本研究旨在探讨单次口服黄芪甲苷IV（AS-IV）对健康年轻成年人脑电图测量的脑振荡和认知相关频谱标志物的急性神经生理效应。20名健康成年人（8名女性，12名男性；平均年龄：23.4±2.1）在口服150 mg AS-IV之前和之后约90分钟进行闭眼静息状态脑电图记录。使用21通道10-20系统收集脑电图数据，并通过伪迹子空间重建和独立成分分析进行清理。使用信噪比和1/f频谱斜率确认数据质量。计算绝对和相对功率值、频段比率和额叶α波不对称性。使用配对t检验或Wilcoxon符号秩检验进行统计比较。δ、θ、β和γ频段的绝对功率降低（P<0.05），但α频段保持稳定。相对α功率显著增加（P = 0.002），相对β、θ和δ功率增加，相对γ功率下降（P = 0.003）。α/β和θ/β比率增加，而δ/α比率降低。额叶α波不对称性未改变。在所有显示出显著变化的数据指标中检查了性别差异；然而，未发现性别依赖性效应。单次AS-IV剂量可能会急性调节脑振荡，支持其潜在的神经活性特性。需要进行更大规模的安慰剂对照试验，包括同时进行心理测量评估，以验证这些发现并将其置于具体情境中。单次AS-IV剂量可能会急性调节脑振荡，支持其潜在的神经活性特性。
