Quatresooz Pascale, Piérard-Franchimont Claudine, Paquet Philippe, Hubert Pascale, Delvenne Philippe, Piérard Gérald E
Department of Dermatopathology, University Hospital Sart Tilman, Liège, Belgium.
Eur J Dermatol. 2008 Jan-Feb;18(1):6-10. doi: 10.1684/ejd.2008.0303. Epub 2007 Dec 18.
Actinic keratoses (AKs) and their derived squamous cell carcinomas are distinctive lesions forming a continuum in a multi-step carcinogenesis process. They are typically found on chronically sun exposed skin. AKs merit to be recognized as such and to be distinguished from squamous cell carcinomas both conceptually and for therapeutic implications. The histological differences between these lesions are well defined and should not be blurred. A brief review is presented about the biological features responsible for AKs and the clinicopathologically distinctive aspects of these lesions. In addition, recent findings are presented about pharmacotherapy using anti-epidermal growth factor receptors, imidazoquinolines, diclofenac-hyaluronan, and methyl aminolevulinate photodynamic therapy.
光化性角化病（AKs）及其衍生的鳞状细胞癌是在多步骤致癌过程中形成连续统一体的独特病变。它们通常出现在长期暴露于阳光下的皮肤。AKs理应被如此认识，并在概念上以及治疗意义上与鳞状细胞癌区分开来。这些病变之间的组织学差异已明确界定，不应被混淆。本文简要回顾了导致AKs的生物学特征以及这些病变在临床病理上的独特方面。此外，还介绍了使用抗表皮生长因子受体、咪唑喹啉、双氯芬酸-透明质酸和甲基氨基乙酰丙酸光动力疗法进行药物治疗的最新发现。
