Garcia-Mouronte Emilio, Naharro-Rodriguez Jorge, Alonso-Mtz de Salinas Luis, Pérez-González Luis Alfonso, Fernández-Guarino Montserrat
Dermatology Department, Hospital Universitario Ramon y Cajal, Carretera M-607 km 9.1, 28034 Madrid, Spain.
Int J Mol Sci. 2025 Jan 13;26(2):628. doi: 10.3390/ijms26020628.
Photodynamic therapy (PDT) involves the topical application of a photosensitizer and its activation by visible light, leading to the generation of protoporphyrin IX (PpIX) and reactive oxygen species. Daylight photodynamic therapy (dPDT), a variant utilizing natural sunlight as the energy source, enhances procedural flexibility by eliminating the need for specialized equipment. dPDT has been effectively used in dermatology to treat various cutaneous disorders, including neoplastic and infectious diseases. Traditionally, skin preparation and photosensitizer application are performed by trained practitioners, limiting the accessibility of dPDT for broader populations. However, recent studies suggest that these preparatory steps can be managed by patients or caregivers, enabling fully self-applied, home-based dPDT protocols. This review systematically examines the current evidence on self-applied dPDT (SA-dPDT), emphasizing molecular mechanisms and its efficacy in managing premalignant and other cutaneous conditions.
光动力疗法（PDT）包括局部应用光敏剂并通过可见光将其激活，从而产生原卟啉IX（PpIX）和活性氧物质。日光光动力疗法（dPDT）是一种利用自然阳光作为能源的变体疗法，通过消除对专业设备的需求提高了操作灵活性。dPDT已在皮肤科有效用于治疗各种皮肤疾病，包括肿瘤性和感染性疾病。传统上，皮肤准备和光敏剂应用由经过培训的从业者进行，这限制了dPDT对更广泛人群的可及性。然而，最近的研究表明，这些准备步骤可由患者或护理人员完成，从而实现完全自我应用的家庭dPDT方案。本综述系统地审视了关于自我应用dPDT（SA-dPDT）的现有证据，重点关注分子机制及其在处理癌前病变和其他皮肤病症方面的疗效。
