Floc'h F, Werner G H
Ann Immunol (Paris). 1976 Mar-Apr;127(2):173-86.
CD-1 or OF-1 mice were inoculated intravenously with 1 mg per mouse (i.e. about 10(6) live bacilli) of Pasteur Institute BCG and challenged 15 to 31 days later with the following viruses introduced by various routes: encephalomyocarditis, murine hepatitis, type 1 and 2 herpes simplex, foot-and-mouth disease and A0 and A2 influenza viruses. In most cases, BCG-inoculated mice exhibited a significantly higher resistance to these lethal infections than control mice (overall survival in control: 18%; in BCG-inoculated mice: 41%). Enhancement of resistance by BCG was especially marked in infections with encephalomyocarditis, herpes simplex type 1 and influenza A2 viruses. Intercurrent infection of BCG-inoculated mice with non lethal doses of viruses did not abrogate their resistance towards subsequent challenge with lethal doses of an unrelated virus. The possible mechanisms of this enhancing effect of BCG on host's resistance are discussed in the light of the known effects of this immunostimulating agent on the various facets of the immune response and of the respective roles the latter play in the defence against virus infections.
给CD - 1或OF - 1小鼠静脉注射每只1毫克（即约10⁶个活芽孢杆菌）的巴斯德研究所卡介苗，15至31天后通过不同途径引入以下病毒进行攻击：脑心肌炎病毒、鼠肝炎病毒、1型和2型单纯疱疹病毒、口蹄疫病毒以及A0和A2流感病毒。在大多数情况下，接种卡介苗的小鼠对这些致死性感染的抵抗力明显高于对照小鼠（对照小鼠的总体存活率为18%；接种卡介苗的小鼠为41%）。卡介苗对抵抗力的增强在脑心肌炎病毒、1型单纯疱疹病毒和A2流感病毒感染中尤为明显。用非致死剂量病毒对接种卡介苗的小鼠进行并发感染，并未消除它们对随后用致死剂量的无关病毒进行攻击的抵抗力。根据这种免疫刺激剂对免疫反应各个方面的已知作用以及后者在抵御病毒感染中所起的各自作用，讨论了卡介苗对宿主抵抗力增强作用的可能机制。
