麻风皮肤损害中的血管生成：对治疗的启示
Angiogenesis in cutaneous lesions of leprosy: implications for treatment.
作者信息
Bhandarkar Sulochana S, Cohen Cynthia, Kuruvila Maria, Rea Thomas H, Mackelfresh Jamie B, Lee Delphine J, Modlin Robert L, Arbiser Jack L
机构信息
Department of Dermatology, Emory University School of Medicine, WMB 5309, 1639 Pierce Dr, Atlanta, GA 30322, USA.
出版信息
Arch Dermatol. 2007 Dec;143(12):1527-9. doi: 10.1001/archderm.143.12.1527.
OBJECTIVE
To examine the potential role of angiogenesis in leprosy.
DESIGN
Immunohistochemical analysis of leprosy lesions.
SETTING
Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University.
PATIENTS
Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients.
MAIN OUTCOME MEASURE
CD31 microvessel counts.
RESULTS
The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions.
CONCLUSIONS
Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.
目的
探讨血管生成在麻风病中的潜在作用。
设计
对麻风病损进行免疫组织化学分析。
单位
卡斯图尔巴医学院皮肤病、性病与麻风病科；加利福尼亚大学洛杉矶分校皮肤科；埃默里大学皮肤科与病理科。
患者
从32例患者获取了代表麻风病谱系的32个皮肤损害。
主要观察指标
CD31微血管计数。
结果
界限类偏结核型、中间界限类及瘤型麻风病损中的平均CD31微血管计数显著高于未定类麻风病损。
结论
细菌载量增加与血管生成增加相关。血管生成抑制剂可能对麻风病治疗有益。
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