Liu Bo-lin, Zhang Xiang, Zhang Wei, Zhen Hai-ning
Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, PR China.
Cancer Biol Ther. 2007 Dec;6(12):1833-6. doi: 10.4161/cbt.6.12.5161. Epub 2007 Oct 13.
Resveratrol is a phytoalexin produced by many plants, and the skin of red grapes is particularly rich in resveratrol which accounts for the "French Paradox". Besides its protection of the cardiovascular system, it can affect the processes underlying all three stages of carcinogenesis, involving tumor initiation, promotion and progression. It has also been shown to suppress angiogenesis and metastasis. The anti-carcinogenic effects of resveratrol appear to be closely associated with its capacity to interact with multiple molecular targets involved in cancer development, while minimizing toxicity in normal tissues as tested. By reviewing many in vitro and in vivo studies, also considering both the supporting and challenging evidences, we are provided with a theory in support of the use of resveratrol in human cancer chemoprevention, in combination with either chemotherapeutic drugs or cytotoxic factors for the highly efficient treatment of drug refractory tumor cells. Anti-carcinogenic potential for cancer chemoprevention and anticancer therapy, which is one of the pleiotropic effects of resveratrol, is so called a new enlightenment of French Paradox.
白藜芦醇是许多植物产生的一种植保素，红葡萄皮中白藜芦醇含量尤其丰富，这就是“法国悖论”的原因所在。除了对心血管系统有保护作用外，它还能影响癌症发生所有三个阶段的潜在过程，包括肿瘤起始、促进和进展。研究还表明它能抑制血管生成和转移。白藜芦醇的抗癌作用似乎与其与癌症发展中涉及的多个分子靶点相互作用的能力密切相关，同时在测试中能将对正常组织的毒性降至最低。通过回顾许多体外和体内研究，同时考虑支持性和挑战性证据，我们得到了一种理论支持，即白藜芦醇可用于人类癌症化学预防，与化疗药物或细胞毒性因子联合使用，以高效治疗耐药肿瘤细胞。白藜芦醇多效性作用之一的癌症化学预防和抗癌治疗的抗癌潜力，就是所谓的“法国悖论”的新启示。
