Jiang Chuan-Hao, Sun Tao-Li, Xiang Da-Xiong, Wei Shan-Shan, Li Wen-Qun
Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Key Laboratory Breeding Base of Hu'nan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, College of Pharmacy, Changsha Medical University, Changsha, China.
Front Pharmacol. 2018 May 22;9:530. doi: 10.3389/fphar.2018.00530. eCollection 2018.
It has been observed that many phytochemicals, frequently present in foods or beverages, show potent chemopreventive or therapeutic properties that selectively affect cancer cells. Numerous studies have demonstrated the anticancer activity of xanthohumol (Xn), a prenylated flavonoid isolated from hops ( L.), with a concentration up to 0.96 mg/L in beer. This review aims to summarize the existing studies focusing on the anticancer activity of Xn and its effects on key signaling molecules. Furthermore, the limitations of current studies and challenges for the clinical use of Xn are discussed.
据观察，许多常见于食品或饮料中的植物化学物质具有强大的化学预防或治疗特性，能够选择性地影响癌细胞。大量研究已证实，从啤酒花（Humulus lupulus L.）中分离出的异戊烯基黄酮——黄腐酚（Xn）具有抗癌活性，在啤酒中的浓度可达0.96毫克/升。本综述旨在总结现有关于Xn抗癌活性及其对关键信号分子影响的研究。此外，还讨论了当前研究的局限性以及Xn临床应用面临的挑战。
