McGuire Amy L, Caulfield Timothy, Cho Mildred K
Amy L. McGuire is at the Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas 77030, USA.
Nat Rev Genet. 2008 Feb;9(2):152-6. doi: 10.1038/nrg2302.
The recent completion of the first two individual whole-genome sequences is a research milestone. As personal genome research advances, investigators and international research bodies must ensure ethical research conduct. We identify three major ethical considerations that have been implicated in whole-genome research: the return of research results to participants; the obligations, if any, that are owed to participants' relatives; and the future use of samples and data taken for whole-genome sequencing. Although the issues are not new, we discuss their implications for personal genomics and provide recommendations for appropriate management in the context of research involving individual whole-genome sequencing.
前两个个体全基因组序列的近期完成是一个研究里程碑。随着个人基因组研究的推进，研究人员和国际研究机构必须确保研究行为符合伦理道德。我们确定了全基因组研究中涉及的三个主要伦理考量因素：将研究结果反馈给参与者；对参与者亲属应尽的义务（如有）；以及全基因组测序所采集样本和数据的未来用途。尽管这些问题并非新问题，但我们讨论了它们对个人基因组学的影响，并针对涉及个体全基因组测序的研究背景下的适当管理提供了建议。
