Zhuang Zhenjing, Su Xiaodong, Yuan Hongyan, Sun Qun, Xiao Dan, Choi Martin M F
College of Chemical Engineering, Sichuan University, Chengdu 610065, PR China.
Analyst. 2008 Jan;133(1):126-32. doi: 10.1039/b712970j. Epub 2007 Nov 5.
CuO nanowires have been prepared and applied for the fabrication of glucose sensors with highly enhanced sensitivity. Cu(OH)(2) nanowires were initially synthesised by a simple and fast procedure, CuO nanowires were then formed simply by removing the water through heat treatment. The structures and morphologies of Cu(OH)(2) and CuO nanowires were characterised by X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy. The direct electrocatalytic oxidation of glucose in alkaline medium at CuO nanowire modified electrodes has been investigated in detail. Compared to a bare Cu electrode, a substantial decrease in the overvoltage of the glucose oxidation was observed at the CuO nanowire electrodes with oxidation starting at ca. 0.10 V vs. Ag/AgCl (saturated KCl). At an applied potential of 0.33 V, CuO nanowire electrodes produce high and reproducible sensitivity to glucose with 0.49 microA/micromol dm(-3). Linear responses were obtained over a concentration range from 0.40 micromol dm(-3) to 2.0 mmol dm(-3) with a detection limit of 49 nmol dm(-3) (S/N = 3). The CuO nanowire modified electrode allows highly sensitive, low working potential, stable, and fast amperometric sensing of glucose, thus is promising for the future development of non-enzymatic glucose sensors.
氧化铜纳米线已被制备并应用于制造具有高度增强灵敏度的葡萄糖传感器。首先通过简单快速的方法合成氢氧化铜纳米线，然后通过热处理去除水分简单地形成氧化铜纳米线。通过X射线衍射、X射线光电子能谱、扫描电子显微镜和透射电子显微镜对氢氧化铜和氧化铜纳米线的结构和形貌进行了表征。详细研究了碱性介质中葡萄糖在氧化铜纳米线修饰电极上的直接电催化氧化。与裸铜电极相比，在氧化铜纳米线电极上观察到葡萄糖氧化过电位大幅降低，氧化起始电位约为相对于Ag/AgCl（饱和KCl）的0.10 V。在0.33 V的施加电位下，氧化铜纳米线电极对葡萄糖具有高且可重复的灵敏度，为0.49 μA/μmol dm⁻³。在0.40 μmol dm⁻³至2.0 mmol dm⁻³的浓度范围内获得线性响应，检测限为49 nmol dm⁻³（S/N = 3）。氧化铜纳米线修饰电极允许对葡萄糖进行高灵敏度、低工作电位、稳定且快速的安培传感，因此对非酶葡萄糖传感器的未来发展具有前景。
