感染旋盘尾丝虫的流动咖啡种植工人对墨西哥伊维菌素治疗地区微丝蚴库维持的作用。

Contribution of migrant coffee labourers infected with Onchocerca volvulus to the maintenance of the microfilarial reservoir in an ivermectin-treated area of Mexico.

作者信息

Rodríguez-Pérez Mario A, Cabrera Aldo Segura, Ortega Cristian Lizarazo, Basáñez María-Gloria, Davies John B

机构信息

Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Blvd, del Maestro esquina Elías Piña, Col, Narciso Mendoza, 88710, Reynosa, Tamaulipas, México.

出版信息

Filaria J. 2007 Dec 18;6:16. doi: 10.1186/1475-2883-6-16.

DOI:10.1186/1475-2883-6-16

PMID:18088423

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2238739/

Abstract

BACKGROUND

Since 1991, in Mexico, ivermectin has been administered twice a year to all residents in the onchocerciasis endemic foci which are mainly located in the coffee growing areas. However, the presence of a potentially infected itinerant seasonal labour force which is not treated regularly could jeopardise the attainment of the 85% coverage which is the present target for elimination of the disease.

METHODS

The prevalence and intensity of Onchocerca volvulus microfilariae (mf), as well as their transmission from humans to vectors, were assessed during the coffee planting-clearing and harvesting seasons of 1997-1998, and 1998-1999 in two localities (I and II) of Southern Chiapas, Mexico, which regularly receive an influx of untreated migrant coffee labourers.

RESULTS

Localities I and II had, respectively, an average of 391 (+/- 32) and 358 (+/- 14) resident inhabitants, and 70 (+/- 52) and 498 (+/- 289) temporary labourers. The ratio of migrants to residents ranged from 0.1:1 in locality I to 2.4:1 in locality II. The proportion of infected Simulium ochraceum s.l. parous flies was significantly lower in locality I than in locality II, and significantly higher during the stay of the migrants than before their arrival or after their departure. Parity and infection were higher in May-July than in November-February (in contrast with the latter being typically considered as the peak onchocerciasis transmission season by S. ochraceum s.l.).

CONCLUSION

The presence of significant numbers of untreated and potentially infected migrants may contribute to ongoing transmission, and their incorporation into ivermectin programmes should be beneficial for the attainment of the elimination goals of the regional initiative. However, the possibility that the results also reflect transmission patterns for the area cannot be excluded and these should be analyzed further.

摘要

背景

自1991年以来，在墨西哥，伊维菌素每年给盘尾丝虫病流行区的所有居民服用两次，这些流行区主要位于咖啡种植区。然而，存在未定期接受治疗的潜在感染流动季节性劳动力可能会危及实现85%的覆盖率这一当前消除该疾病的目标。

方法

在1997 - 1998年以及1998 - 1999年的咖啡种植清理和收获季节，对墨西哥恰帕斯州南部两个地区（I和II）的旋盘尾丝虫微丝蚴（mf）的流行率和强度及其从人类向媒介的传播情况进行了评估，这两个地区经常有未接受治疗的流动咖啡劳工涌入。

结果

地区I和地区II分别平均有391（±32）和358（±14）名常住居民，以及70（±52）和498（±289）名临时工。移民与居民的比例从地区I的0.1:1到地区II的2.4:1不等。感染的赭色蚋属（Simulium ochraceum s.l.）已产卵雌蝇的比例在地区I显著低于地区II，且在移民逗留期间显著高于他们到来之前或离开之后。5 - 7月的孕卵和感染情况高于11月至次年2月（与此相反，后者通常被认为是赭色蚋属传播盘尾丝虫病的高峰季节）。