Suuriniemi Miia, Suominen Harri, Mahonen Anitta, Alen Markku, Cheng Sulin
Dept. Of Cell Biology, University of Jyvaskyla, Finland.
Pediatr Exerc Sci. 2007 Nov;19(4):444-58. doi: 10.1123/pes.19.4.444.
This follow-up study confirms our previous findings that the ER-alpha PvuII polymorphism (Pp) modulates the association between exercise and bone mass. The differences in bone properties of girls with consistently low physical activity (LLPA) and consistently high physical activity (HHPA) were evident only in those bearing the heterozygote ER-alpha genotype (Pp). In particular, areal bone mineral density of the total femur, bone mineral content and areal bone mineral density of the femoral neck, and bone mineral content and cortical thickness of the tibia shaft were significantly (p < .05) lower in the Pp girls with LLPA than in their HHPA counterparts. These findings might partly explain the genetic basis of human variation associated with exercise training.
这项随访研究证实了我们之前的发现，即雌激素受体α PvuII多态性（Pp）调节运动与骨量之间的关联。身体活动持续较低（LLPA）和身体活动持续较高（HHPA）的女孩在骨特性方面的差异仅在那些具有杂合子雌激素受体α基因型（Pp）的女孩中明显。具体而言，LLPA的Pp女孩的总股骨面积骨密度、股骨颈骨矿物质含量和面积骨密度，以及胫骨干的骨矿物质含量和皮质厚度均显著（p < 0.05）低于其HHPA的对应女孩。这些发现可能部分解释了与运动训练相关的人类变异的遗传基础。
