Clark Clifford P
Winter Park, Fla. From the University of South Florida and private practice.
Plast Reconstr Surg. 2007 Nov;120(6 Suppl):27S-32S. doi: 10.1097/01.prs.0000248806.70402.7b.
Successful clinical application of dermal filler products requires an understanding of their physical characteristics and in vivo behavior. This study reviewed the data for hyaluronic acid dermal filler products derived from an animal source--the rooster comb.
A review of the hyaluronic acid literature was performed. Clinical experience with the animal-derived hyaluronic acid products was evaluated.
The source of the hyaluronic acid has not been demonstrated to be a clinically important point of differentiation among filler products. Hypersensitivity reactions are rare and are also present in the products derived from bacteria. Variations that effect the hyaluronic acid products' physical characteristics and clinical performance are more closely related to cross-linking and formulation. Hyaluronic acid gel derived from animal sources is cross-linked by a sulfonyl-bis-ethyl bond and is a soft gel compared with other hyaluronic acid products. There is minimal gel swelling, which results in modest postinjection edema. Optimal clinical application favors patients who desire quick recovery and minimal palpability.
Hyaluronic acid skin filler products derived from an animal source are safe and effective. Successful clinical application should be based on an understanding of the patient's goals and the choice of a hyaluronic acid product with the optimal characteristics.
真皮填充产品的成功临床应用需要了解其物理特性和体内行为。本研究回顾了来源于动物（公鸡鸡冠）的透明质酸真皮填充产品的数据。
对透明质酸文献进行了综述。评估了动物源性透明质酸产品的临床经验。
透明质酸的来源尚未被证明是填充产品之间临床上重要的区分点。过敏反应很少见，在细菌来源的产品中也存在。影响透明质酸产品物理特性和临床性能的差异与交联和配方更为密切相关。动物源性透明质酸凝胶通过磺酰基双乙酯键交联，与其他透明质酸产品相比是一种软凝胶。凝胶肿胀最小，导致注射后水肿程度适中。最佳临床应用适合那些希望快速恢复且触摸感最小的患者。
动物源性透明质酸皮肤填充产品安全有效。成功的临床应用应基于对患者目标的理解以及选择具有最佳特性的透明质酸产品。
