Carruthers Alastair, Carruthers Jean
Vancouver, British Columbia, Canada From the Departments of Dermatology and Skin Science and Ophthalmology and Visual Sciences, University of British Columbia.
Plast Reconstr Surg. 2007 Nov;120(6 Suppl):33S-40S. doi: 10.1097/01.prs.0000248808.75700.5f.
Recent advances in the technology and biocompatibility of the hyaluronans in all skin types mean that they are becoming the temporary facial filling agents of choice for many aesthetic physicians and surgeons.
The hyaluronan products that have been approved for clinical usage by the U.S. Food and Drug Administration and Health Canada were reviewed with respect to their composition, clinical effects and safety profiles, and potential complications.
The currently approved accepted standard for the hyaluronan family of fillers of nonanimal bacterial origin includes Restylane and Perlane in the United States and Perlane, Restylane Touch, and SubQ in Canada. Also of nonanimal origin, Juvéderm 24HV, 30, and 30HV were approved by the Food and Drug Administration in June of 2006. Another bacteria-derived hyaluronan filler is Captique; the Hylaform group of hyaluronan fillers is of animal origin and appears to be similar in effect and longevity to Captique.
The remarkable biocompatibility of the hyaluronan group of agents in individuals of all skin types, allied with the superior aesthetic result and outstanding longevity of response, promises that patients will continue to demand safe these recent advances in filler technology.
透明质酸在所有皮肤类型中的技术和生物相容性方面的最新进展意味着，它们正成为许多美容医生和外科医生首选的临时面部填充剂。
对已获美国食品药品监督管理局和加拿大卫生部批准用于临床的透明质酸产品，就其成分、临床效果、安全性概况及潜在并发症进行了综述。
目前已获批准的非动物细菌来源的透明质酸填充剂家族的公认标准产品在美国包括瑞蓝和乔雅登雅致，在加拿大包括乔雅登雅致、瑞蓝触感和乔雅登基础。同样为非动物来源的乔雅登24HV、30和30HV于2006年6月获美国食品药品监督管理局批准。另一种细菌衍生的透明质酸填充剂是卡普缇，透明质酸填充剂海魅属于动物来源，其效果和持久性似乎与卡普缇相似。
透明质酸类制剂在所有皮肤类型个体中具有显著的生物相容性，再加上卓越的美学效果和出色的持久反应，预示着患者将继续要求使用这些安全的填充技术最新进展产品。
