Edsman Katarina L M, Öhrlund Åke
*Both authors are affiliated with the Research & Development, Galderma, Uppsala, Sweden.
Both authors are affiliated with the Research & Development, Galderma, Uppsala, Sweden.
Dermatol Surg. 2018 Apr;44(4):557-562. doi: 10.1097/DSS.0000000000001370.
There are several published articles on characterization of fillers, describing methods for both chemical and physicochemical characterization. Recently a lot of focus has been on the development of methods for measuring cohesion of hyaluronic acid (HA) fillers.
The aim of this study is to investigate and compare the drop-weight method and the correlation between cohesion and other physicochemical properties using a variety of HA fillers.
HA fillers covering several product families and manufacturing techniques were used. The HA fillers also covered a range of HA concentrations from 12 to 24 mg/mL. Cohesion was determined using sensory evaluation and the drop-weight method. Other physicochemical properties evaluated were rheology and the swelling factor.
In this study, it was verified that values obtained by the drop-weight method reflect the perceived cohesion very well. The correlation with rheology is affected by the HA concentration in the products. A remarkably good correlation between swelling factor and cohesion was found.
Cohesion correlates with other physicochemical methods. It could be discussed whether there is a need for a separate cohesion method because other already established physicochemical methods such as rheology and swelling factor can describe the underlying properties that affect cohesion.
有几篇已发表的关于填充剂特性描述的文章，介绍了化学和物理化学特性描述方法。最近，很多焦点集中在透明质酸（HA）填充剂内聚力测量方法的开发上。
本研究旨在使用多种HA填充剂研究并比较落锤法以及内聚力与其他物理化学性质之间的相关性。
使用了涵盖多个产品系列和制造技术的HA填充剂。这些HA填充剂的HA浓度范围也为12至24mg/mL。通过感官评估和落锤法测定内聚力。评估的其他物理化学性质为流变学和膨胀因子。
在本研究中，证实落锤法获得的值能很好地反映感知到的内聚力。与流变学的相关性受产品中HA浓度的影响。发现膨胀因子与内聚力之间存在非常好的相关性。
内聚力与其他物理化学方法相关。由于流变学和膨胀因子等其他已确立的物理化学方法可以描述影响内聚力的潜在性质，因此是否需要单独的内聚力方法值得探讨。
