Canedo Paulo, Castanheira-Vale Abel J, Lunet Nuno, Pereira Fábio, Figueiredo Céu, Gioia-Patricola Lydie, Canzian Federico, Moreira Herculano, Suriano Gianpaolo, Barros Henrique, Carneiro Fátima, Seruca Raquel, Machado José C
IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal.
Eur J Cancer Prev. 2008 Feb;17(1):28-32. doi: 10.1097/CEJ.0b013e32809b4d0f.
It has been demonstrated that polymorphisms within inflammation-related genes are associated with risk of gastric carcinoma in Helicobacter pylori-infected individuals. Recently, several studies have reported conflicting results regarding the association between the interleukin (IL)8-251*T/*A polymorphism and risk of gastric carcinoma. In this study, we performed a case-control analysis, including 693 controls, 187 chronic gastritis cases and 333 gastric carcinoma cases, to determine the association between the IL8-251 polymorphism and risk of chronic gastritis and gastric carcinoma in the northern Portugal population. We found no significant association between the IL8-251 polymorphism and increased risk of chronic gastritis or gastric carcinoma, in agreement with that reported in other populations of white origin. The retrospective analysis of published data shows that the association between the IL8-251 polymorphism and risk of gastric carcinoma tends to be reproducible in populations of Asian origin. The estimated effect of the polymorphism under analysis was not significantly different in subgroups of gastric carcinoma cases defined by histologic type and anatomic site of the tumours, and by sex and age of the participants. In conclusion our results indicate that although the IL8-251 polymorphism might be a relevant host susceptibility factor for gastric carcinoma development, this association is likely to be ethnic-specific.
业已证明，炎症相关基因内的多态性与幽门螺杆菌感染个体的胃癌风险相关。最近，几项研究报告了白细胞介素（IL）8 - 251*T/*A多态性与胃癌风险之间的关联存在相互矛盾的结果。在本研究中，我们进行了一项病例对照分析，纳入693名对照、187例慢性胃炎病例和333例胃癌病例，以确定IL8 - 251多态性与葡萄牙北部人群慢性胃炎和胃癌风险之间的关联。我们发现IL8 - 251多态性与慢性胃炎或胃癌风险增加之间无显著关联，这与其他白种人群的报道一致。对已发表数据的回顾性分析表明，IL8 - 251多态性与胃癌风险之间的关联在亚洲人群中往往具有可重复性。在所分析的多态性的估计效应在根据肿瘤的组织学类型和解剖部位、参与者的性别和年龄定义的胃癌病例亚组中无显著差异。总之，我们的结果表明，尽管IL8 - 251多态性可能是胃癌发生的一个相关宿主易感性因素，但这种关联可能具有种族特异性。
