Bennett David, Bendersky Margaret, Lewis Michael
Department of Psychiatry, Drexel University College of Medicine, Philadelphia, PA, USA.
J Dev Behav Pediatr. 2007 Dec;28(6):467-72. doi: 10.1097/DBP.0b013e31811320d8.
To examine the effect of prenatal cocaine exposure on health risk behaviors during preadolescence.
The present study examined prenatal cocaine exposure, gender, and environmental risk as predictors of self-reported substance use, aggression, and a disregard for safety precautions on the Youth Risk Behavior Survey in a sample of 10.5 year olds (n = 154, including 60 who were prenatally exposed to cocaine).
Gender tended to moderate the effects of prenatal cocaine exposure because exposure effects were found for boys but not girls. Boys who were prenatally exposed to cocaine reported engaging in more high-risk behavior. In examining individual outcomes, cocaine exposed boys had the highest scores for aggression, substance use, and a disregard for safety precautions, although these differences were significant only for the composite health risk behavior measure.
The findings extend earlier work showing that prenatal cocaine exposure places boys at risk for problems of inhibitory control, emotional regulation, and antisocial behavior. Research is needed to examine whether the effects of prenatal cocaine on health risk behaviors persist into adolescence, when such behaviors tend to increase.
研究产前可卡因暴露对青春期前健康风险行为的影响。
本研究以10.5岁儿童为样本（n = 154，其中60名在产前暴露于可卡因），考察产前可卡因暴露、性别和环境风险，将其作为青少年风险行为调查中自我报告的物质使用、攻击行为以及对安全预防措施漠视情况的预测因素。
性别往往会调节产前可卡因暴露的影响，因为仅在男孩中发现了暴露效应，而女孩中未发现。产前暴露于可卡因的男孩报告称参与了更多高风险行为。在考察个体结果时，暴露于可卡因的男孩在攻击行为、物质使用和对安全预防措施的漠视方面得分最高，尽管这些差异仅在综合健康风险行为测量中具有显著性。
这些发现扩展了早期的研究成果，表明产前可卡因暴露使男孩面临抑制控制、情绪调节和反社会行为问题的风险。需要开展研究，以考察产前可卡因对健康风险行为的影响是否会持续到青春期，因为在青春期此类行为往往会增加。
