Carfrae Matthew J, Holtzman Adrian, Eames Fred, Parnes Steven M, Lupinetti Allison
Albany Medical Center, Albany, NY, USA.
Laryngoscope. 2008 Mar;118(3):501-5. doi: 10.1097/MLG.0b013e31815c1a61.
To determine whether 3 Tesla (T) magnetic resonance imaging (MRI) with delayed contrast imaging has sufficient anatomic resolution to image the intracochlear fluid spaces (i.e., the scala tympani, scala media, and scala vestibuli) of the inner ear and identify endolymphatic hydrops in vivo.
Four normal subjects underwent 3T MRI scanning after the administration of gadodiamide intravenous (IV) contrast. MRI region of interest signal intensity was used to determine the diffusion of gadodiamide into the perilymphatic fluid spaces over time. Seven subjects with unilateral Ménière's disease underwent 3T MRI 4 hours after administration of gadodiamide IV contrast agent.
All four normal subjects demonstrated perilymphatic enhancement by 4 hours postinjection. Loss of definition of the membranous cochlea was noted in five of the seven subjects with Ménière's disease. Precise definition of the scala media could not be achieved with this imaging protocol.
Delayed contrast imaging of the inner ear with 3T MRI revealed in vivo changes of the membranous labyrinth consistent with unilateral Ménière's disease.
确定3特斯拉（T）磁共振成像（MRI）延迟对比成像是否具有足够的解剖分辨率来对内耳的蜗内液腔（即鼓阶、中阶和前庭阶）进行成像，并在活体中识别内淋巴积水。
4名正常受试者静脉注射钆双胺（IV）造影剂后接受3T MRI扫描。利用MRI感兴趣区域的信号强度来确定钆双胺随时间向内淋巴液腔的扩散情况。7名单侧梅尼埃病患者在静脉注射钆双胺造影剂4小时后接受3T MRI检查。
所有4名正常受试者在注射后4小时均显示内淋巴增强。7名梅尼埃病患者中有5名出现膜迷路清晰度丧失。采用该成像方案无法精确显示中阶。
3T MRI对内耳进行延迟对比成像显示了与单侧梅尼埃病一致的膜迷路活体变化。
