Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Department of Otolaryngology, Head and Neck Surgery & Audiology and Neurotology, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden.
Sci Rep. 2021 Mar 30;11(1):7212. doi: 10.1038/s41598-021-86589-1.
Ménière disease (MD) is an idiopathic inner ear disorder, and endolymphatic hydrops (EH) being considered to be its pathological basis. Currently, there is no gold standard for diagnosing MD. Previous study has reported visualized EH using MRI by intratympanic gadolinium-based contrast media (GBCM) administration (IT-Gd) in patients with MD, and this technique was gradually established for MD diagnosis. However, few studies reported their diagnostic sensitivity and specificity in clinical application. This prospective study aimed at investigating the clinical characteristics and magnetic resonance imaging (MRI) results of patients with MD, and analyzing the relationship between clinical results and MRI findings in MD patients. Our study shows that the diagnostic sensitivity and specificity of MRI were 79.2% and 80.7% respectively. Moreover, there was no significant correlation between hearing levels and cochlear grading scores, nor vestibular grading scores. The duration of disease was not significantly associated with cochlear or vestibular grading scores. These findings suggest that IT-Gd MRI offers reliable radiological diagnostic criteria for MD.
梅尼埃病（MD）是一种特发性内耳疾病，内淋巴积水（EH）被认为是其病理基础。目前，MD 尚无金标准诊断方法。既往研究报道，使用鼓室内钆基对比剂（GBCM）给药（IT-Gd）的 MRI 可显示 MD 患者的 EH，该技术逐渐被确立用于 MD 诊断。然而，临床应用中很少有研究报道其诊断的敏感性和特异性。本前瞻性研究旨在探讨 MD 患者的临床特征和磁共振成像（MRI）结果，并分析 MD 患者的临床结果与 MRI 发现之间的关系。我们的研究表明，MRI 的诊断敏感性和特异性分别为 79.2%和 80.7%。此外，听力水平与耳蜗分级评分、前庭分级评分之间无显著相关性。疾病持续时间与耳蜗或前庭分级评分无显著相关性。这些发现表明，IT-Gd MRI 为 MD 提供了可靠的影像学诊断标准。
