Kawahata Kimito, Yamaguchi Masao, Kanda Hiroko, Komiya Akiko, Tanaka Ryoichi, Dohi Makoto, Misaki Yoshikata, Yamamoto Kazuhiko
Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Mod Rheumatol. 2008;18(1):52-6. doi: 10.1007/s10165-007-0002-3. Epub 2007 Dec 20.
Airway involvement clinically presenting as dyspnea and an obstructive ventilatory defect is a rare but clinically important complication in systemic lupus erythematosus (SLE), since the airway manifestation is often progressive and resistant to systemic immunosuppressive therapy. Here we report two SLE patients with slowly progressive airflow limitation, which was clinically thought to be bronchiolitis obliterans. Both patients showed obvious improvement after inhalation of anticholinergics was started. Because anticholinergics are highly safe and never immunosuppressive, inhalation of these drugs might be useful in the therapeutic strategies for airflow limitation accompanying SLE or other collagen diseases.
气道受累在临床上表现为呼吸困难和阻塞性通气功能障碍，这在系统性红斑狼疮（SLE）中是一种罕见但临床上重要的并发症，因为气道表现通常呈进行性且对全身免疫抑制治疗有抵抗性。在此，我们报告两名SLE患者，他们存在缓慢进展的气流受限，临床上认为是闭塞性细支气管炎。两名患者在开始吸入抗胆碱能药物后均有明显改善。由于抗胆碱能药物安全性高且无免疫抑制作用，吸入这些药物可能有助于SLE或其他胶原病伴发气流受限的治疗策略。
