Toubi E
Division of Allergy and Clinical Immunology, Bnai-Zion Medical Center, Technion, Rapaport, Faculty of Medicine, Haifa, Israel.
Clin Rev Allergy Immunol. 2008 Jun;34(3):338-44. doi: 10.1007/s12016-007-8043-0.
Among the several mechanisms that play role in maintaining peripheral self-tolerance is the existence of a unique CD4+CD25+ population of naturally occurring regulatory T (Treg) cells that actively prevent both the activation and the effector function of autoreactive T cells that have escaped different mechanisms of tolerance. Many studies have shown the benefit of targeting this cell population by restoring self-tolerance. Therapies that could possibly increase the suppressive ability of T regulatory cells were proven to improve that course of autoimmune diseases.
在维持外周自身耐受的多种机制中，存在一种独特的自然发生的调节性T（Treg）细胞群体，即CD4+CD25+细胞，它能积极阻止已逃脱不同耐受机制的自身反应性T细胞的激活和效应功能。许多研究表明，通过恢复自身耐受来靶向这一细胞群体具有益处。事实证明，可能增强调节性T细胞抑制能力的疗法能够改善自身免疫性疾病的病程。
