自身免疫中的天然调节性 T 细胞。
Natural regulatory T cells in autoimmunity.
机构信息
Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1670, USA.
出版信息
Autoimmunity. 2011 Feb;44(1):33-42. doi: 10.3109/08916931003782155. Epub 2010 Nov 23.
Abstract
The suppressive/immunomodulatory function of CD4(+)CD25(+)FOXP3(+) regulatory T (Treg) cells is crucial for the maintenance of immune homeostasis, which helps to prevent autoimmunity and reduce the inflammation induced by pathogens and environmental insults. This review summarizes the current knowledge on the types and mechanisms of action of Treg cells and their role in the immune tolerance to self-antigens, with a particular focus on naturally occurring Treg cells.
摘要
CD4(+)CD25(+)FOXP3(+) 调节性 T（Treg）细胞的抑制/免疫调节功能对于维持免疫稳态至关重要，有助于防止自身免疫和减轻病原体和环境损伤引起的炎症。本文综述了 Treg 细胞的类型和作用机制及其在自身抗原免疫耐受中的作用的最新知识，特别关注天然存在的 Treg 细胞。
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