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本文引用的文献

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Regulatory T cells exert checks and balances on self tolerance and autoimmunity.调节性 T 细胞对自身耐受和自身免疫起着制衡作用。
Nat Immunol. 2010 Jan;11(1):7-13. doi: 10.1038/ni.1818. Epub 2009 Dec 17.
2
Regulatory T cells and inhibitory cytokines in autoimmunity.自身免疫中的调节性T细胞和抑制性细胞因子。
Curr Opin Immunol. 2009 Dec;21(6):612-8. doi: 10.1016/j.coi.2009.09.011. Epub 2009 Oct 23.
3
How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets.调节性T细胞的及时消融如何在胰岛内引发自身免疫性病变。
Immunity. 2009 Oct 16;31(4):654-64. doi: 10.1016/j.immuni.2009.08.023. Epub 2009 Oct 8.
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Mechanisms of foxp3+ T regulatory cell-mediated suppression.Foxp3+调节性T细胞介导的抑制机制。
Immunity. 2009 May;30(5):636-45. doi: 10.1016/j.immuni.2009.04.010.
5
Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?天然和适应性Foxp3+调节性T细胞：是同质性还是分工不同？
Immunity. 2009 May;30(5):626-35. doi: 10.1016/j.immuni.2009.05.002.
6
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.表达FoxP3转录因子的人CD4+ T细胞的功能划分与分化动力学
Immunity. 2009 Jun 19;30(6):899-911. doi: 10.1016/j.immuni.2009.03.019. Epub 2009 May 21.
7
Regulatory T cells: key players in tolerance and autoimmunity.调节性T细胞：耐受与自身免疫中的关键角色。
Endocrinol Metab Clin North Am. 2009 Jun;38(2):265-72, vii. doi: 10.1016/j.ecl.2009.01.002.
8
Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures.潜伏相关肽（LAP）和白细胞介素-1受体I/II型（CD121a/CD121b）在活化的人FOXP3 +调节性T细胞上的选择性表达，使得它们能够从扩增培养物中纯化出来。
Blood. 2009 May 21;113(21):5125-33. doi: 10.1182/blood-2009-01-199950. Epub 2009 Mar 18.
9
Natural Tregs and autoimmunity.天然调节性T细胞与自身免疫
Front Biosci (Landmark Ed). 2009 Jan 1;14(1):333-43. doi: 10.2741/3247.
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The Critical Role of TGF-beta1 in the Development of Induced Foxp3+ Regulatory T Cells.转化生长因子β1在诱导性Foxp3 +调节性T细胞发育中的关键作用
Int J Clin Exp Med. 2008;1(3):192-202. Epub 2008 Jun 10.

自身免疫中的天然调节性 T 细胞。

Natural regulatory T cells in autoimmunity.

机构信息

Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1670, USA.

出版信息

Autoimmunity. 2011 Feb;44(1):33-42. doi: 10.3109/08916931003782155. Epub 2010 Nov 23.

DOI:10.3109/08916931003782155
PMID:21091291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3057884/
Abstract

The suppressive/immunomodulatory function of CD4(+)CD25(+)FOXP3(+) regulatory T (Treg) cells is crucial for the maintenance of immune homeostasis, which helps to prevent autoimmunity and reduce the inflammation induced by pathogens and environmental insults. This review summarizes the current knowledge on the types and mechanisms of action of Treg cells and their role in the immune tolerance to self-antigens, with a particular focus on naturally occurring Treg cells.

摘要

CD4(+)CD25(+)FOXP3(+) 调节性 T（Treg）细胞的抑制/免疫调节功能对于维持免疫稳态至关重要，有助于防止自身免疫和减轻病原体和环境损伤引起的炎症。本文综述了 Treg 细胞的类型和作用机制及其在自身抗原免疫耐受中的作用的最新知识，特别关注天然存在的 Treg 细胞。