TGF-β 诱导的 CD4(+) Foxp3(+) 调节性 T 细胞在自身免疫性疾病中的治疗潜力。
Therapeutic potential of TGF-β-induced CD4(+) Foxp3(+) regulatory T cells in autoimmune diseases.
机构信息
Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USA.
出版信息
Autoimmunity. 2011 Feb;44(1):43-50. doi: 10.3109/08916931003782163. Epub 2010 Jul 29.
Foxp3(+) T regulatory cell (Treg) subsets play a crucial role in the maintenance of immune homeostasis against self-antigens. The lack or dysfunction of these cells contributes to the pathogenesis and development of many autoimmune diseases. Therefore, manipulation of these cells may provide a novel therapeutic approach to treat autoimmune diseases. In this review, we provide current opinions concerning the classification, developmental, and functional characterization of Treg subsets. Particular emphasis will be focused on the therapeutic role of TGF-β-induced CD4M(+) Foxp3(+) cells (iTregs) in established autoimmune disease. Moreover, the similarity and diversity of iTregs and naturally occurring, thymus-derived CD4(+) CD25(+) Foxp3(+) regulatory T cells (nTregs) will be discussed, including the finding that the pro-inflammatory cytokine IL-6 can convert nTregs to IL-17-producing cells, whereas iTregs induced by TGF-β are resistant to the effects of this cytokine. Understanding these aspects may help to determine how Tregs can be used in the treatment of autoimmune diseases.
Foxp3(+) T 调节细胞 (Treg) 亚群在对抗自身抗原的免疫稳态维持中发挥着关键作用。这些细胞的缺乏或功能障碍导致许多自身免疫性疾病的发病机制和发展。因此，对这些细胞的操纵可能为治疗自身免疫性疾病提供一种新的治疗方法。在这篇综述中，我们提供了关于 Treg 亚群的分类、发育和功能特征的最新观点。特别强调了 TGF-β 诱导的 CD4M(+) Foxp3(+) 细胞 (iTregs) 在已建立的自身免疫性疾病中的治疗作用。此外，还将讨论 iTregs 和天然产生的、胸腺来源的 CD4(+) CD25(+) Foxp3(+) 调节性 T 细胞 (nTregs) 的相似性和多样性，包括发现促炎细胞因子 IL-6 可以将 nTregs 转化为产生 IL-17 的细胞，而 TGF-β 诱导的 iTregs 则对这种细胞因子的作用具有抗性。了解这些方面可能有助于确定如何将 Tregs 用于治疗自身免疫性疾病。
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