Ulusoy Rifat Eralp, Karabudak Ozlem, Kilicaslan Fethi, Kirilmaz Ata, Us Melih Hulusi, Cebeci Bekir Sitki
Department of Cardiology, Gulhane Haydarpasa Military Medical School, 34670 Uskudar-Istanbul, Turkey.
Rheumatol Int. 2008 May;28(7):617-21. doi: 10.1007/s00296-007-0491-6. Epub 2007 Dec 19.
Noninvasive assessment of endothelial dysfunction (ED) and diagnosing the early vascular development of atherosclerosis in active mucocutaneous Behçet's disease. Twenty-nine active BD patients (study group) without any obstructive vascular involvement were compared with twenty-nine healthy controls (control group) in terms of ED utilizing endothelium-dependent dilation as well as endothelium-independent dilation (FMD), which was assessed by measuring changes in brachial artery diameter following sublingual glyceril trinitrate (400 microg Nitrolingual spray). All patients underwent a complete transthoracic echocardiographic and tissue Doppler study. A standard form was utilized for the documentation of the presence or absence of the known risk factors for atherosclerotic vascular disease. Statistical analysis was performed by utilizing SPSS version 11. There was no difference between patients and controls in terms of echocardiographic and tissue Doppler parameters as well as baseline brachial artery diameters. Flow-mediated dilation showed 38% impairment in study group compared with control (P<0.05). Endothelium-independent NTG dilatation did not differ in both groups. Ultrasonography is an easily applicable noninvasive method for following BD patients for the risk of ED, which may preclude to atherosclerosis, save time and cost-effective.
活动性黏膜皮肤型白塞病内皮功能障碍（ED）的无创评估及动脉粥样硬化早期血管病变的诊断。选取29例无任何阻塞性血管病变的活动性白塞病患者（研究组），与29例健康对照者（对照组），通过测量舌下含服硝酸甘油（400微克硝酸甘油喷雾剂）后肱动脉直径的变化，利用内皮依赖性舒张及非内皮依赖性舒张（FMD）来评估ED。所有患者均接受完整的经胸超声心动图和组织多普勒检查。使用标准表格记录动脉粥样硬化性血管疾病已知危险因素的有无。采用SPSS 11版软件进行统计分析。患者与对照组在超声心动图和组织多普勒参数以及肱动脉基线直径方面无差异。与对照组相比，研究组的血流介导的舒张功能受损38%（P<0.05）。两组的非内皮依赖性硝酸甘油舒张功能无差异。超声检查是一种易于应用的无创方法，可用于随访白塞病患者ED风险，这可能预防动脉粥样硬化，节省时间且具有成本效益。
