白塞病中的血管内皮功能与血浆同型半胱氨酸水平
Vascular endothelial function and plasma homocysteine levels in Behcet's disease.
作者信息
Ozdemir Ramazan, Barutcu Irfan, Sezgin Alpay T, Acikgoz Nusret, Ermis Necip, Esen Ali Metin, Topal Ergun, Bariskaner Emrah, Ozerol Ibrahim
机构信息
Department of Cardiology, Faculty of Medicine, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey.
出版信息
Am J Cardiol. 2004 Aug 15;94(4):522-5. doi: 10.1016/j.amjcard.2004.04.073.
The purpose of the present study was to test endothelial function and to determine if plasma homocysteine levels are associated with endothelial injury in patients with Behcet's disease (BD). Flow-mediated dilation in patients with BD was smaller than that of control subjects (p = 0.001), and mean plasma homocysteine levels in patients with BD were significantly higher (p = 0.0001). On regression analysis, only mean plasma homocysteine concentration was independently related to flow-mediated dilation (F = 5.7, p = 0.001).
本研究的目的是检测白塞病（BD）患者的内皮功能，并确定血浆同型半胱氨酸水平是否与内皮损伤相关。BD患者的血流介导的血管舒张小于对照组（p = 0.001），且BD患者的平均血浆同型半胱氨酸水平显著更高（p = 0.0001）。回归分析显示，只有平均血浆同型半胱氨酸浓度与血流介导的血管舒张独立相关（F = 5.7，p = 0.001）。
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