Szekely C A, Breitner J C S, Zandi P P
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Int Rev Psychiatry. 2007 Dec;19(6):693-706. doi: 10.1080/09540260701797944.
The already considerable public health burden of Alzheimer's disease will likely worsen as populations around the world age. As a result, there is considerable motivation to develop effective strategies for preventing the disease. A wide variety of such strategies are under investigation and include pharmaceuticals, nutriceuticals, diet, physical activity and cognitive activity. We review here the most promising candidates and the epidemiologic evidence for their efficacy. Although none of these have yet to be definitively shown to prevent Alzheimer's disease, further research should help to clarify what role they may play in reducing the burden of this disease.
随着全球人口老龄化，阿尔茨海默病已然相当沉重的公共卫生负担可能会进一步加重。因此，人们有强烈的动机去制定有效的疾病预防策略。目前正在研究各种各样的此类策略，包括药物、营养保健品、饮食、体育活动和认知活动。我们在此回顾最有前景的候选策略及其有效性的流行病学证据。尽管这些策略均尚未被明确证明可预防阿尔茨海默病，但进一步的研究应有助于阐明它们在减轻该疾病负担方面可能发挥的作用。
