Cecen Emre, Uysal Kamer Mutafoglu, Ozguven Aykan, Gunes Dilek, Irken Gulersu, Olgun Nur
Department of Pediatric Oncology, Dokuz Eylül University, Institute of Oncology, Izmir, Turkey.
Pediatr Hematol Oncol. 2007 Dec;24(8):615-21. doi: 10.1080/08880010701640390.
Although veno-occlusive disease of the liver is a well-known complication of high-dose chemotherapy and bone marrow transplantation, it has rarely been observed in children who receive conventional chemotherapy. Most cases in the literature consists of children with Wilms tumor. It has been very uncommon in rhabdomyosarcoma patients until recently, although they commonly receive similar anticancer agents. Here the authors report a 2-year-old boy with rhabdomyosarcoma who developed veno-occlusive disease while receiving VAC (vincristine, actinomycin D, cyclophosphamide) chemotherapy regimen according to the IRS-IV protocol. The patient gradually recovered during 2 weeks with supportive treatment only.
虽然肝静脉闭塞病是高剂量化疗和骨髓移植的一种众所周知的并发症，但在接受传统化疗的儿童中很少观察到。文献中的大多数病例是患有肾母细胞瘤的儿童。直到最近，横纹肌肉瘤患者中这种病一直非常罕见，尽管他们通常接受类似的抗癌药物治疗。在此，作者报告一名2岁的横纹肌肉瘤男孩，他在按照IRS-IV方案接受VAC（长春新碱、放线菌素D、环磷酰胺）化疗方案期间发生了肝静脉闭塞病。仅通过支持治疗，该患者在2周内逐渐康复。
