Weemaes C M, Bakkeren J A, Haraldsson A, Smeets D F
Department of Pediatrics, University Hospital, Nijmegen, The Netherlands.
Ann Genet. 1991;34(3-4):201-5.
Longitudinal immunological studies were performed in five patients with Bloom's syndrome. Serum IgG concentration showed no age-related increase. IgA levels were below the 10th percentile in childhood, but rose to normal in all but one. IgM was decreased in four patients at diagnosis and remained so in three of them. Cellular immunity results were very variable, even within one patient. An immunologic attrition was not demonstrated.
对5例布卢姆综合征患者进行了纵向免疫学研究。血清IgG浓度未显示出与年龄相关的增加。IgA水平在儿童期低于第10百分位数，但除1例患者外，其他患者的IgA水平均升至正常。4例患者在诊断时IgM降低，其中3例患者的IgM水平持续降低。细胞免疫结果差异很大，即使在同一患者体内也是如此。未证实存在免疫耗竭。
