Hlebowicz Joanna, Darwiche Gassan, Björgell Ola, Almér Lars-Olof
Department of Medicine, University of Lund, Malmö University Hospital, Malmö, Sweden.
BMC Gastroenterol. 2007 Dec 20;7:46. doi: 10.1186/1471-230X-7-46.
Previous studies on healthy people show that vinegar delays gastric emptying and lowers postprandial blood glucose and insulin levels. The aim of this study was to investigate the effect of apple cider vinegar on delayed gastric emptying rate on diabetes mellitus patients.
Ten patients with type 1 diabetes and diabetic gastroparesis, including one patient who had undergone vagotomy, were included and completed the investigator blinded crossover trial. The gastric emptying rate (GER) was measured using standardized real-time ultrasonography. The GER was calculated as the percentage change in the antral cross-sectional area 15 and 90 minutes after ingestion of 300 g rice pudding and 200 ml water (GER1), or 300 g rice pudding and 200 ml water with 30 ml apple cider vinegar (GER2). The subjects drank 200 ml water daily before breakfast one week before the measurement of GER1. The same subjects drank 200 ml water with 30 ml vinegar daily before breakfast for two weeks before the measurement of GER2.
The median values of GER1 and GER2 were 27% and 17%, respectively. The effect of vinegar on the rate of gastric emptying was statistically significant (p < 0.05).
This study shows that vinegar affects insulin-dependent diabetes mellitus patients with diabetic gastroparesis by reducing the gastric emptying rate even further, and this might be a disadvantage regarding to their glycaemic control.
ISRCTN33841495.
先前针对健康人群的研究表明，醋可延缓胃排空，并降低餐后血糖和胰岛素水平。本研究旨在探讨苹果醋对糖尿病患者胃排空延迟率的影响。
纳入10例1型糖尿病合并糖尿病胃轻瘫患者，其中1例曾接受迷走神经切断术，所有患者均完成了研究者设盲的交叉试验。采用标准化实时超声测量胃排空率（GER）。GER计算方法为摄入300克米布丁和200毫升水后15分钟和90分钟时胃窦横截面积的变化百分比（GER1），或摄入300克米布丁、200毫升水和30毫升苹果醋后15分钟和90分钟时胃窦横截面积的变化百分比（GER2）。在测量GER1前一周，受试者每天早餐前饮用200毫升水。在测量GER2前两周，同一受试者每天早餐前饮用含30毫升醋的200毫升水。
GER1和GER2的中位数分别为27%和17%。醋对胃排空率的影响具有统计学意义（p < 0.05）。
本研究表明，醋通过进一步降低胃排空率影响胰岛素依赖型糖尿病合并糖尿病胃轻瘫患者，这可能不利于他们的血糖控制。
ISRCTN33841495。
