Mia Md Al-Tareq, Mosaib Md Golam, Khalil Md Ibrahim, Islam Md Asiful, Gan Siew Hua
Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
Department of Biochemistry and Molecular Biology, Gono University, Savar, Dhaka 1344, Bangladesh.
Foods. 2020 Oct 28;9(11):1557. doi: 10.3390/foods9111557.
Diabetes is a chronic metabolic disorder triggered by disturbances in carbohydrate, protein, and lipid metabolisms, where either reduced secretion or sensitivity of insulin is observed coupled with poor glucose control. Date palm fruits are one of the fruits reported to have good potential in diabetes treatment due to its presence of polyphenols exerting strong antioxidant activities. Other possible mechanisms of action include the polyphenolic compounds, which can inhibit enzymes like α-amylase and α-glucosidase. Flavonoids in dates can stimulate β-cells by increasing the number of islets and β-cells, recovering endocrine pancreatic tissues, reducing β-cell apoptosis, activating insulin receptors following the increase in insulin secretion, in addition to improving diabetes-induced complications. In this review, the in vitro, in vivo, and human study-based evidence of date palm as an anti-diabetic fruit is summarised.
糖尿病是一种由碳水化合物、蛋白质和脂质代谢紊乱引发的慢性代谢性疾病，其特征为胰岛素分泌减少或敏感性降低，同时血糖控制不佳。海枣果实是据报道在糖尿病治疗方面具有良好潜力的水果之一，因为其含有具有强大抗氧化活性的多酚。其他可能的作用机制包括多酚类化合物，它们可以抑制α-淀粉酶和α-葡萄糖苷酶等酶。海枣中的类黄酮可以通过增加胰岛和β细胞的数量、恢复胰腺内分泌组织、减少β细胞凋亡、在胰岛素分泌增加后激活胰岛素受体来刺激β细胞，此外还可以改善糖尿病引起的并发症。在这篇综述中，总结了基于体外、体内和人体研究的海枣作为抗糖尿病水果的证据。
