[临床确诊多发性硬化症患者的磁共振成像与诱发电位对比研究]

[Comparative study of magnetic resonance and evoked potentials in patients with clinically defined multiple sclerosis].

作者信息

Iriarte J, de Castro P, Gudín M, Martínez-Lage J M

机构信息

Departamento de Neurología. Clínica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona.

出版信息

Neurologia. 1991 Nov;6(9):322-7.

PMID:1809338

Abstract

In an attempt to establish the efficacy of the most recent diagnostic tests--magnetic resonance (MR) imaging and multimodal evoked potentials (EP), 28 patients with clinically definite multiple sclerosis (MS) (1.a Poser's categories) were studied. The MR was positive in 26 (92%) patients; the EP were altered in 23 (82%)--the visual EP in 18 (64.2%), the auditory EP in 5 (17.8%), and the somatosensory EP in 15 (53.5%). Three patients with abnormal brain stem MR had normal EP. Two patients had normal MR and altered EP. There was not any patient with normal MR and EP. The MR was the most sensitive technique for the diagnosis of MS, but only during the 3 first years of evolution. After this study we consider the convenience to have both MR and EP positive to give a patient the diagnostic of clinically definite with paraclinic support (category 1.b of Poser).

摘要

为确定最新诊断测试——磁共振（MR）成像和多模式诱发电位（EP）的有效性，对28例临床确诊为多发性硬化症（MS）（波泽分类法1.a类）的患者进行了研究。26例（92%）患者的MR检查呈阳性；23例（82%）患者的EP检查有异常——视觉EP异常的有18例（64.2%），听觉EP异常的有5例（17.8%），躯体感觉EP异常的有15例（53.5%）。3例脑干MR检查异常的患者EP检查正常。2例患者MR检查正常但EP检查异常。没有MR和EP检查均正常的患者。MR是诊断MS最敏感的技术，但仅在疾病发展的头3年有效。经过这项研究，我们认为为了在有辅助临床检查支持的情况下（波泽分类法1.b类）对患者做出临床确诊诊断，MR和EP检查结果均为阳性是合适的。