凋亡细胞的磷脂酰丝氨酸与吞噬细胞的TIM-4：“吃我”信号。
Apoptotic PS to phagocyte TIM-4: eat me.
作者信息
Savill John, Gregory Chris
机构信息
MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
出版信息
Immunity. 2007 Dec;27(6):830-2. doi: 10.1016/j.immuni.2007.12.002.
PMID:18093535
Abstract
Although cells dying by apoptosis expose the classical "eat me" signal phosphatidylserine (PS), a phagocytic transmembrane receptor for PS has proved elusive. Now cell and structural studies (Kobayashi et al. [2007] and Santiago et al. [2007] in this issue of Immunity) implicate the type I molecule TIM-4.
摘要
尽管通过凋亡死亡的细胞会暴露经典的“吃我”信号磷脂酰丝氨酸（PS），但PS的吞噬性跨膜受体却一直难以捉摸。现在，细胞和结构研究（本期《免疫》杂志中Kobayashi等人[2007年]以及Santiago等人[2007年]的研究）表明I型分子TIM-4与之有关。
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