Gandhi Chintan, Zalawadia Rishit, Balaraman R
Pharmacy Department, Faculty of Technology and Engineering, M. S. University of Baroda, Kalabhavan, Baroda, Gujarat, India.
Ren Fail. 2008;30(9):921-30. doi: 10.1080/08860220802353900.
Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. The objective of the present study was to examine the role of nebivolol in modulating peroxynitrite species-induced inflammation and apoptosis after renal warm ischemia/reperfusion injury in rats. The present study was designed to investigate the effects of nebivolol on the renal warm ischemia/reperfusion injury in rats treated with the nitric oxide synthase inhibitor, N(omega)-nitro-L-arginine methyl ester. After right nephrectomy, nebivolol was administered for 15 days. On the 16(th) day, ischemia was induced in contra lateral kidney for 45 min, followed by reperfusion for 24 hr. Renal function, inflammation, and apoptosis were estimated at the end of 24 hr reperfusion. Nebivolol improved the renal dysfunction and reduced inflammation and apoptosis after renal ischemia/reperfusion injury. In conclusion, nebivolol shows potent anti-apoptotic and anti-inflammatory properties due to its NO-releasing property. These findings may have major implications in the treatment of human ischemic acute renal failure.
缺血/再灌注损伤在肾脏外科手术或移植领域较为常见，是急性肾衰竭的主要原因。本研究的目的是探讨奈必洛尔在调节大鼠肾脏热缺血/再灌注损伤后过氧亚硝酸盐诱导的炎症和细胞凋亡中的作用。本研究旨在研究奈必洛尔对用一氧化氮合酶抑制剂N（ω）-硝基-L-精氨酸甲酯治疗的大鼠肾脏热缺血/再灌注损伤的影响。右肾切除术后，给予奈必洛尔15天。在第16天，对侧肾脏进行45分钟的缺血，然后再灌注24小时。在再灌注24小时结束时评估肾功能炎症和细胞凋亡情况。奈必洛尔改善了肾脏缺血/再灌注损伤后的肾功能障碍，减少了炎症和细胞凋亡。总之，奈必洛尔因其释放一氧化氮的特性而具有强大的抗凋亡和抗炎特性。这些发现可能对人类缺血性急性肾衰竭的治疗具有重要意义。
