Delgadillo-Valero Luis Fernando, Hernández-Cruz Estefani Yaquelin, Pedraza-Chaverri José
Faculty of Medicine, National Autonomous University of Mexico, Mexico City 04360, Mexico.
Laboratory F-315, Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City 04510, Mexico.
Life (Basel). 2023 Mar 10;13(3):752. doi: 10.3390/life13030752.
Ozone (O) is a reactive oxygen species (ROS) that can interact with cellular components and cause oxidative stress. Following said logic, if O induces such a stressful milieu, how does it exert antioxidant functions? This is mediated by controlled toxicity produced by low concentrations of O, which enhance the cell's suppliance of antioxidant properties without causing any further damage. Therapeutic concentrations vary extensively, although 50 µg/mL is commonly used in experimental and clinical procedures, given that augmented concentrations might work as germicides or cause endogenous damage. O therapy has been shown to be effective when applied before or after traumatic renal procedures, whether caused by ischemia, xenobiotics, chronic damage, or other models. In this review, we focus on discussing the role of O therapy in different models of kidney damage associated with fibrosis, apoptosis, oxidative stress, and inflammation. We integrate and report knowledge about O in renal therapy, debunking skepticism towards unconventional medicine, explaining its proven therapeutic properties, and thus providing background for its use in further research as well as in clinical settings.
臭氧（O）是一种活性氧（ROS），它可以与细胞成分相互作用并引起氧化应激。按照上述逻辑，如果O会诱导这样一种应激环境，那么它是如何发挥抗氧化功能的呢？这是由低浓度O产生的可控毒性介导的，这种毒性可增强细胞的抗氧化特性供应，而不会造成任何进一步的损害。治疗浓度差异很大，尽管在实验和临床程序中通常使用50µg/mL，因为更高的浓度可能会起到杀菌剂的作用或导致内源性损伤。已证明，在创伤性肾脏手术之前或之后应用O疗法都是有效的，无论创伤是由缺血、外源性物质、慢性损伤还是其他模型引起的。在这篇综述中，我们重点讨论O疗法在与纤维化、细胞凋亡、氧化应激和炎症相关的不同肾脏损伤模型中的作用。我们整合并报告有关O在肾脏治疗中的知识，消除对非常规医学的怀疑，解释其已证实的治疗特性，从而为其在进一步研究以及临床环境中的应用提供背景。
