Michel-Batôt Christine, Dintinger Hervé, Blum Alain, Olivier Pierre, Laborde Fyriel, Bettembourg-Brault Isabelle, Pourel Jacques, Loeuille Damien, Chary-Valckenaere Isabelle
Rheumatology Department, Brabois Teaching Hospital, CHU Brabois, 54000 Nancy, France.
Joint Bone Spine. 2008 Jan;75(1):78-83. doi: 10.1016/j.jbspin.2007.02.006. Epub 2007 Aug 29.
Only about 40 cases of septic arthritis of the facet joints have been reported to date. We report 6 new cases including 2 at the cervical spine, which is rarely involved. Mean age was 61.5 years; there were 5 men and 1 woman. Spinal pain and stiffness, fever, and asthenia were the presenting manifestations. Laboratory tests consistently showed inflammation. Among classical risk factors for infection, only noninsulin-dependent diabetes was noted, in a single patient. Mean time to the diagnosis was 42 days. Discitis, a far more common condition, was considered initially, and early radiographs were of limited diagnostic assistance. Radionuclide bone scans identified the site of the infection and served to look for other foci. Magnetic resonance imaging was effective in confirming the diagnosis at an early stage and in looking for local spread (muscles, epidural space, and disk). L3-L4 was involved in 3 patients, C4-C5 in 2, and L4-L5 in 1. Direct inoculation during mesotherapy sessions was the cause in 1 patient. Cultures of blood and needle biopsy samples were positive in all 6 cases; Staphylococcus aureus was the causative agent in 3 patients. The risk of local and systemic complications governs the prognosis of facet joint infection. Of our 6 patients, 4 experienced complications: there was 1 case each of discitis, epidural infection, endocarditis, and septic arthritis of the acromioclavicular joint. Fatal multiple organ dysfunction occurred in 1 patient. In the other 5 patients, antimicrobial therapy and protection from weight-bearing for 3 months ensured a favorable outcome.
迄今为止,仅报告了约40例小关节化脓性关节炎。我们报告6例新病例,其中包括2例颈椎受累,颈椎受累情况很少见。平均年龄为61.5岁;男性5例,女性1例。脊柱疼痛、僵硬、发热和乏力为主要表现。实验室检查始终显示有炎症。在感染的经典危险因素中,仅1例患者存在非胰岛素依赖型糖尿病。平均诊断时间为42天。最初考虑为更为常见的椎间盘炎,早期X线片诊断价值有限。放射性核素骨扫描确定了感染部位并用于寻找其他病灶。磁共振成像在早期确诊及寻找局部扩散(肌肉、硬膜外间隙和椎间盘)方面有效。3例患者累及L3-L4,2例累及C4-C5,1例累及L4-L5。1例患者的病因是在中医疗法治疗期间直接接种。所有6例患者的血液和针吸活检样本培养均呈阳性;3例患者的病原体为金黄色葡萄球菌。局部和全身并发症的风险决定了小关节感染的预后。我们的6例患者中,4例出现并发症:分别为1例椎间盘炎、1例硬膜外感染、1例心内膜炎和1例肩锁关节化脓性关节炎。1例患者发生致命的多器官功能障碍。其他5例患者采用抗菌治疗并避免负重3个月,结果良好。