Falconer Karolin, Gonzalez Veronica D, Reichard Olle, Sandberg Johan K, Alaeus Annette
Karolinska Institutet, Department of Medicine Solna, Infectious Diseases Unit, SE-17176 Stockholm, Sweden.
J Clin Virol. 2008 Feb;41(2):160-3. doi: 10.1016/j.jcv.2007.11.005.
BACKGROUND/OBJECTIVE: Spontaneous HCV clearance in HCV/HIV-1 coinfected patients is likely to be very rare given the damage to the immune system caused by HIV-1 infection. The search for immune correlates of spontaneous clearance is important for the understanding of pathogenesis as well as for the development of possible new treatment strategies.
STUDY DESIGN/RESULTS: A cohort of HCV/HIV-1 coinfected patients was followed. Plasma HCV viral load was measured and T cell immunity in peripheral blood samples was assessed using multi-color flow cytometry. One HCV/HIV-1 coinfected patient spontaneously became HCV-RNA negative after being positive for several years. This patient displayed a normalized CD4 counts on successful HAART, low level of T cell activation and a high level of T cell function as compared to HCV/HIV-1 coinfected control subjects.
A beneficial immune status including a low level of chronic T cell activation and a high level of T cell function may be one factor that contributes to improved chances of clearance of chronic HCV infection in HIV-1 infected patients.
背景/目的：鉴于HIV-1感染对免疫系统造成的损害，丙型肝炎病毒（HCV）/HIV-1合并感染患者中自发清除HCV的情况可能非常罕见。寻找自发清除的免疫相关因素对于理解发病机制以及开发可能的新治疗策略至关重要。
研究设计/结果：对一组HCV/HIV-1合并感染患者进行了随访。检测血浆HCV病毒载量，并使用多色流式细胞术评估外周血样本中的T细胞免疫。一名HCV/HIV-1合并感染患者在HCV RNA阳性数年之后自发转为阴性。与HCV/HIV-1合并感染的对照受试者相比，该患者在成功进行高效抗逆转录病毒治疗（HAART）后CD4细胞计数恢复正常，T细胞活化水平较低，T细胞功能水平较高。
包括慢性T细胞活化水平低和T细胞功能水平高在内的有益免疫状态可能是提高HIV-1感染患者清除慢性HCV感染几率的一个因素。
