Sakauchi Fumio, Oura Asae, Ohnishi Hirofumi, Mori Mitsuru
Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan.
J Epidemiol. 2007 Nov;17(6):210-4. doi: 10.2188/jea.17.210.
In Asia there are few reports considering time intervals in the examination of clinical features of primary biliary cirrhosis (PBC). Therefore, we tried to compare the characteristics of patients with PBC in two different years.
In two fiscal years (1999 and 2004), 9,761 and 13,142 patients with symptomatic PBC were registered to receive public financial aid from the Ministry of Health, Labour and Welfare of Japan, respectively. For the present study, clinical data from 2,127 patients in 1999 and 6,423 ones in 2004 were available. We compared the data in the two different years, including sex, age, major symptoms, and laboratory data.
Male/female ratios were the same figure (0.13 for 1999 and 2004). The median age was significantly older in 2004 than in 1999 (59 years for 1999, 63 years for 2004, respectively, p<0.01). Jaundice and esophageal varices were found significantly less frequent in 2004 than in 1999 (p<0.01 for each item). Levels of total bilirubin,gamma-glutamyl transpeptidase (gamma-GTP), total cholesterol, and immunoglobulin M were significantly lower in 2004 than in 1999 (p< 0.02 for total bilirubin, and p<0.01 for other each item). The positive rate of antimitochondrial antibodies was significantly higher in 1999 than in 2004 (87.0% for 1999, 83.5% for 2004, respectively, p<0.01)). Complicated autoimmune diseases such as Sjögren's syndrome, rheumatoid arthritis, and chronic thyroiditis were found significantly more frequent in 2004 than in 1999 (p<0.01 for each item).
Among the patients with PBC in 2004, an increase in median age, and lower levels of laboratory data such as gamma-GTP have been found compared to 1999. These results may show an accumulation of patients with better prognosis and the recent medical progress in controlling patients with PBC.J Epidemiol 2007; 17: 210-214.
在亚洲，很少有关于原发性胆汁性肝硬化（PBC）临床特征检查时间间隔的报道。因此，我们试图比较不同年份PBC患者的特征。
在两个财政年度（1999年和2004年），分别有9761例和13142例有症状的PBC患者登记接受日本厚生劳动省的公共财政援助。在本研究中，可获得1999年2127例患者和2004年6423例患者的临床数据。我们比较了这两个不同年份的数据，包括性别、年龄、主要症状和实验室数据。
男性/女性比例相同（1999年和2004年均为0.13）。2004年的中位年龄显著高于1999年（1999年为59岁，2004年为63岁，p<0.01）。2004年黄疸和食管静脉曲张的发生率显著低于1999年（每项p<0.01）。2004年总胆红素、γ-谷氨酰转肽酶（γ-GTP）、总胆固醇和免疫球蛋白M水平显著低于1999年（总胆红素p<0.02，其他每项p<0.01）。抗线粒体抗体阳性率1999年显著高于2004年（1999年为87.0%，2004年为83.5%，p<0.01）。2004年干燥综合征、类风湿关节炎和慢性甲状腺炎等并发自身免疫性疾病的发生率显著高于1999年（每项p<0.01）。
与1999年相比，2004年PBC患者的中位年龄增加，γ-GTP等实验室数据水平降低。这些结果可能表明预后较好的患者有所积累，以及近期在控制PBC患者方面的医学进展。《流行病学杂志》2007年；17：210 - 214。
