Sawyer Laura J, Starritt Hazel C, Hiscock Sarah C, Evans Martyn J
Department of Medical Physics and Bioengineering, Royal United Hospital, Bath, UK.
Nucl Med Commun. 2008 Feb;29(2):144-9. doi: 10.1097/MNM.0b013e3282f258ef.
Nuclear medicine scans may be accompanied by CT acquisitions to provide localization of radioisotope uptake through image fusion and for use in attenuation correction. The effective doses to patients resulting from radioisotope administrations and from diagnostic CT scans are well documented. However, the development of gamma cameras with low dose CT attachments introduces the requirement for calculation of effective doses arising from non-standard CT acquisitions. In this study, the CT function of the GE Infinia Hawkeye was investigated and effective doses were calculated using various methods in order to assess the suitability of standard CT dose calculation methods.
Dose measurements were performed using Perspex head and body phantoms and the results were used in three calculation methods: (1) the ImPACT CT dosimetry calculator used Monte Carlo dose data to calculate effective doses; (2) organ fractions exposed by each scan were estimated and applied to dose measurements and ICRP tissue weighting factors; (3) standard conversion factors were used with measured and displayed dose indices to provide the simplest method of calculation.
The maximum variation in effective dose using each calculation method was within 10% of the mean. Average effective doses from CT scans acquired using the Hawkeye were 0.9 mSv for a chest scan, 1.5 mSv for an abdomen-pelvis scan, and 0.1 mSv for a head scan, all significantly lower than doses resulting from diagnostic CT scans.
These doses may be used for justification of radiation exposures in accordance with IR(ME)R 2000, in association with the accompanying radioisotope dose.
核医学扫描可能会伴随CT采集,以通过图像融合提供放射性同位素摄取的定位,并用于衰减校正。放射性同位素给药和诊断性CT扫描给患者带来的有效剂量已有充分记录。然而,带有低剂量CT附件的伽马相机的发展带来了计算非标准CT采集产生的有效剂量的需求。在本研究中,对GE Infinia Hawkeye的CT功能进行了研究,并使用各种方法计算有效剂量,以评估标准CT剂量计算方法的适用性。
使用有机玻璃头部和体模进行剂量测量,并将结果用于三种计算方法:(1)ImPACT CT剂量测定计算器使用蒙特卡罗剂量数据计算有效剂量;(2)估计每次扫描所暴露的器官分数,并将其应用于剂量测量和国际放射防护委员会组织权重因子;(3)将标准转换因子与测量和显示的剂量指数一起使用,以提供最简单的计算方法。
使用每种计算方法时,有效剂量的最大变化在平均值的10%以内。使用Hawkeye进行CT扫描的平均有效剂量,胸部扫描为0.9 mSv,腹部-骨盆扫描为1.5 mSv,头部扫描为0.1 mSv,均显著低于诊断性CT扫描产生的剂量。
根据2000年《电离辐射防护与辐射源安全基本标准》,这些剂量可用于证明与伴随的放射性同位素剂量相关的辐射暴露的合理性。