Segerer S, Schlöndorff D
Medizinische Poliklinik, University of Munich, Munich, Germany.
Kidney Int. 2008 Mar;73(5):533-7. doi: 10.1038/sj.ki.5002734. Epub 2007 Dec 19.
B lymphocytes are part of the inflammatory cells recruited to the human kidney in various disease settings. B cell infiltrates have been described in renal allografts, in acute and chronic interstitial nephritis, and the most common glomerular diseases like immunoglobulin A (IgA) and membranous nephropathy. These cells are almost exclusively recruited to the tubulointerstitium, but not the glomerular tuft. In addition to diffuse tubulointerstitial infiltrates, B cells together with T cells and dendritic cells form organized nodular aggregates surrounded by neo-lymphatic vessels. The functional significance of these tertiary lymphoid organs remains to be fully defined. Intrarenal B cells may be part of a local system to enhance the immunological response by functioning as antigen presenting cells, and as a source for cytokines promoting T-cell proliferation and lymphatic neoangiogenesis. In this way, they could enhance the local immune response to persisting autoantigens in the tubulointerstitium.
B淋巴细胞是在各种疾病情况下被招募到人类肾脏的炎性细胞的一部分。在肾移植、急性和慢性间质性肾炎以及最常见的肾小球疾病如免疫球蛋白A（IgA）肾病和膜性肾病中均有B细胞浸润的描述。这些细胞几乎只被招募到肾小管间质，而不是肾小球。除了弥漫性肾小管间质浸润外，B细胞与T细胞和树突状细胞一起形成由新生淋巴管包围的有组织的结节状聚集物。这些三级淋巴器官的功能意义仍有待充分明确。肾内B细胞可能是局部系统的一部分，通过作为抗原呈递细胞发挥作用，并作为促进T细胞增殖和淋巴管新生血管形成的细胞因子来源，从而增强免疫反应。通过这种方式，它们可以增强对肾小管间质中持续存在的自身抗原的局部免疫反应。
