Costa Henrique Olival, Ruschi e Luchi Giulliano Enrico, Augusto Arthur Guilerme, Castro Marilia, de Souza Flavia Coelho
Otorhinolaryngology Department, São Paulo Santa Casa.
Braz J Otorhinolaryngol. 2007 Sep-Oct;73(5):627-31. doi: 10.1016/s1808-8694(15)30122-1.
Experimental models for clinical studies of rhinosinusitis are needed.
to define a reliable, solid and reproducible experimental model for inflammatory rhinosinusitis with no innoculation of infectious agents in rabbits.
Experimental.
Twenty 20 rabbits were divided into 4 groups submitted to 4 different interventions: the placement of a unilateral nasal fossa sponge, unilateral obliteration of the nasal ostium with cyanoacrylate, unilateral placement of antigens in the maxillary cavity and unilateral placement of blood in the maxillary cavity. The animals were monitored for 15 days and then anesthetized and sacrificed; the maxillary sinuses were evaluated histologicaly and results were compared with controls and between the intervention groups.
Sponje and glue as agents of meatal obstruction and toxoid applied in the antrum are efficient as methods for rhinosinusitis modeling. Blood was not efficient in producing sinusitis.
需要用于鼻窦炎临床研究的实验模型。
建立一种可靠、稳定且可重复的炎性鼻窦炎实验模型，不对兔子接种感染因子。
实验性研究。
20只兔子分为4组，接受4种不同干预：单侧鼻窝放置海绵、用氰基丙烯酸酯单侧闭塞鼻道、在上颌窦单侧放置抗原以及在上颌窦单侧放置血液。对动物进行15天监测，然后麻醉并处死；对上颌窦进行组织学评估，并将结果与对照组以及各干预组之间进行比较。
作为鼻道阻塞剂的海绵和胶水以及在上颌窦应用类毒素是有效的鼻窦炎建模方法。血液在引发鼻窦炎方面效果不佳。
