Puga Fernanda, Sampaio Isabel, Veiga Heloisa, Ferreira Camila, Cagy Maurício, Piedade Roberto, Ribeiro Pedro
Laboratório de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Avenida Venceslau Brás 71, Rio de Janeiro, RJ, Brazil.
Arq Neuropsiquiatr. 2007 Dec;65(4A):955-9. doi: 10.1590/s0004-282x2007000600006.
The early stages of visual information processing, involving the detection and perception of simple visual stimuli, have been demonstrated to be sensitive to psychotropic agents. The present study investigated the effects of an acute dose of bromazepam (3 mg), compared with placebo, on the P100 component of the visual evoked potential and reaction time. The sample, consisting of 14 healthy subjects (6 male and 8 female), was submitted to a visual discrimination task, which employed the "oddball" paradigm. Results suggest that bromazepam (3 mg) impairs the initial stage of visual information processing, as observed by an increase in P100 latency.
视觉信息处理的早期阶段，涉及简单视觉刺激的检测和感知，已被证明对精神药物敏感。本研究调查了与安慰剂相比，急性剂量的溴西泮（3毫克）对视觉诱发电位P100成分和反应时间的影响。样本由14名健康受试者（6名男性和8名女性）组成，他们接受了采用“异常球”范式的视觉辨别任务。结果表明，如P100潜伏期增加所示，溴西泮（3毫克）损害了视觉信息处理的初始阶段。
